Effects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study.
Purpose: Acute intervention with wild blueberry (WBB) has previously revealed positive cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles o...
| Published in: | European Journal of Nutrition Vol. 60; no. 8; pp. 4263 - 4279 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Dec2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153436535&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153436535 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2021 vid: 60 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 153436535 150451322 153436535 153436535 10.1007/s00394-021-02588-y 153436535 ppf: 4263 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Effects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study. aug: au: Barfoot, Katie Louise Istas, Geoffrey Feliciano, Rodrigo Pedro Lamport, Daniel Joseph Riddell, Patricia Rodriguez-Mateos, Ana Williams, Claire Michelle affil: School of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights Road, Reading, UK sug: subj: Cognition Drug Effects Metabolites Drug Effects Blueberry Pharmacodynamics Executive Function Flavonoids Pharmacodynamics Human Pilot Studies Child Post Hoc Analysis Task Performance and Analysis Urinalysis Child: 6-12 years ab: Purpose: Acute intervention with wild blueberry (WBB) has previously revealed positive cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles of children following berry consumption, to our knowledge. A study of this kind could provide insight into a mechanism of action for the cognitive and mood improvements observed previously in children. The aim of this pilot study was to assess cognitive performance and urinary metabolite concentrations in healthy 7–10-year-old children across a 4 week daily WBB drink intervention. Methods: This pilot study examined the effects of daily WBB consumption for 4 weeks (766 mg total polyphenols; 253 mg anthocyanins; equivalent to 240 g fresh blueberries per day) on cognition and mood in 15 healthy 7–10-year-old children. Polyphenol metabolites were measured in 24 h urine before and after the 4 week intervention. Results: Chronic WBB-related benefits were seen on cognitively demanding trials on the modified attention network task, a task measuring executive functioning. Specifically, the WBB group maintained significantly higher accuracy on incongruent trials (96%; SE 0.03) compared with placebo participants (85%; SE 0.03; p = 0.038) after the 4 week intervention, suggesting WBB was of most benefit on the more difficult aspects of the task. No significant WBB-related effects were observed on the auditory verbal learning task or the child's version of the positive and negative affect schedule. Urinary metabolite analyses indicated significant increases in different metabolites in WBB and placebo groups after 4 week consumption. Conclusion: The research demonstrates 24 h WBB bioavailability in a child cohort for the first time with increases in urinary hippuric acid excretion during 2 week daily WBB consumption. This study highlights the importance of conducting a larger study in children investigating the mechanism of action behind cognitive effects using bioavailability data. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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