Urinary sodium and potassium excretion and cerebrovascular health: a multimodal imaging study.
Purpose: Dietary sodium and potassium intake are associated with stroke, but the potential mechanisms are unclear. We aimed to study the association between sodium and potassium intake and subclinical cerebrovascular health in hypertensive older males using multimodal magnetic resonance imaging. Met...
| Publicado en: | European Journal of Nutrition Vol. 60; no. 8; pp. 4555 - 4564 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | equations & formulas research Journal Article |
| Publicado: |
Springer Nature
Dec2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153436551&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153436551 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2021 vid: 60 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 153436551 150961148 153436551 153436551 10.1007/s00394-021-02612-1 153436551 ppf: 4555 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Urinary sodium and potassium excretion and cerebrovascular health: a multimodal imaging study. aug: au: Liu, Wenjin Huang, Xiaoqin Liu, Xuebing Wang, Lulu Chen, Zhensen Ortega, Dakota Chen, Li Sun, Jie Hatsukami, Thomas S. Yuan, Chun Li, Haige Yang, Junwei affil: Department of Radiology, University of Washington, Seattle, WA, USA sug: subj: Hypertension Sodium Potassium Food Intake Cerebrovascular Disorders Risk Factors Risk Assessment Human Male Middle Age Aged Sodium Urine Potassium Urine Magnetic Resonance Imaging Cerebrovascular Circulation Regression Middle Aged: 45-64 years Aged: 65+ years Male ab: Purpose: Dietary sodium and potassium intake are associated with stroke, but the potential mechanisms are unclear. We aimed to study the association between sodium and potassium intake and subclinical cerebrovascular health in hypertensive older males using multimodal magnetic resonance imaging. Methods: A total of 189 hypertensive male subjects without previous cardiovascular or cerebrovascular disease were included. Daily urinary sodium and potassium excretion were estimated from a fasting spot urine sample using a formula approach. A dedicated cerebrovascular health imaging protocol including vessel wall imaging, angiography, arterial spin labeling imaging and T2-weighted fluid-attenuated inversion recovery imaging was performed to study intracranial atherosclerosis, vascular rarefaction (defined as fewer discernible vessels on angiography), brain perfusion and small vessel disease, respectively. Results: The mean age was 64.9 (± 7.2) years. The average daily urinary and potassium excretion was 4.7 (± 1.4) g/L and 2.1 (± 0.5) g/L, respectively. Increased urinary sodium excretion was associated with decreased cerebral blood flow and elevated urinary potassium excretion was associated with reduced prevalence of intracranial plaque. The associations remained significant after adjusting for covariates, even including blood pressure control. Quadratic regression analysis indicated a marginally significant U-shaped association between urinary sodium intake and white matter hyperintensity, which lost significance in fully adjusted models. No significant association of urinary sodium and potassium excretion with other cerebrovascular health measures was noted. Conclusion: We concluded that in hypertensive older males without overt cardiovascular disease, increased sodium intake and reduced potassium intake are associated with impaired subclinical cerebrovascular health. pubtype: Academic Journal doctype: equations & formulas research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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