Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study.

Suicidal behavior (SB) is a major problem in patients with substance use disorders (SUDs). However, little is known about specific SB risk factors in this population, and pathogenetic hypotheses are difficult to disentangle. This study investigated some SB and SUD-related endophenotypes, such as imp...

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Publicado en:International Journal of Mental Health & Addiction Vol. 19; no. 5; pp. 1729 - 1745
Autores principales: Costanza, Alessandra, Rothen, Stéphane, Achab, Sophia, Thorens, Gabriel, Baertschi, Marc, Weber, Kerstin, Canuto, Alessandra, Richard-Lepouriel, Hélène, Perroud, Nader, Zullino, Daniele
Formato: Artículo
Publicado: Springer Nature Oct2021
Materias:
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Oct2021
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      pub: Springer Nature
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        153473054
        10.1007/s11469-020-00259-3
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        atl: Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study.
      aug:
        au:
          Costanza, Alessandra
          Rothen, Stéphane
          Achab, Sophia
          Thorens, Gabriel
          Baertschi, Marc
          Weber, Kerstin
          Canuto, Alessandra
          Richard-Lepouriel, Hélène
          Perroud, Nader
          Zullino, Daniele
        affil:
          Department of Psychiatry, Faculty of Medicine, University of Geneva, rue Michel Servet 1, 1211, Geneva 4, Switzerland
          Department of Psychiatry, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy
          Addiction Unit, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
          Service of General Psychiatry and Psychotherapy, Nant Foundation, Montreux, Switzerland
          Division of Institutional Measures, Medical Direction, University Hospitals of Geneva, Geneva, Switzerland
          Service of Psychiatric Specialties, Department of Psychiatry, University Hospitals of Geneva, Geneva, Switzerland
          Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
      su:
        Substance abuse
        Impulsive personality
        Suicidal behavior
        Risk-taking behavior
        Attempted suicide
      sug:
        subj:
          Substance abuse
          Impulsive personality
          Suicidal behavior
          Risk-taking behavior
          Attempted suicide
      keyword:
        Aggression
        Anger
        Impulsivity
        Substance use disorder
        Aggression
        Anger
        Impulsivity
        Substance use disorder
      ab: Suicidal behavior (SB) is a major problem in patients with substance use disorders (SUDs). However, little is known about specific SB risk factors in this population, and pathogenetic hypotheses are difficult to disentangle. This study investigated some SB and SUD-related endophenotypes, such as impulsivity, aggression, trait anger, and risk-taking behaviors (RTBs), in forty-eight patients with SUDs in relation to lifetime history of suicide attempts (SAs). Disorders related to alcohol, cannabis, cocaine, opiates, and hallucinogenic drugs were included. Lifetime SAs was significantly associated with both higher impulsivity and higher aggression, but not with trait anger. A higher number of RTBs were associated with lifetime SAs and higher impulsivity, but not with aggression and trait anger. Assessing these endophenotypes could refine clinical SB risk evaluation in SUDs patients by detecting higher-risk subgroups. An important limitation of this study is exiguity of its sample size. Its primary contribution is inclusion of all SUD types.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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