Psychometric Properties of Rapid Word-Based Rate Measures in the Assessment of Bulbar Amyotrophic Lateral Sclerosis: Comparisons With Syllable-Based Rate Tasks.
Purpose: Rapid maximum performance repetition tasks have increasingly demonstrated their utility as clinimetric markers supporting diagnosis and monitoring of bulbar disease in amyotrophic lateral sclerosis (ALS). A recently developed protocol uses novel real-word repetitions instead of traditional...
| Publicado en: | Journal of Speech, Language & Hearing Research Vol. 64; no. 11; pp. 4178 - 4192 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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American Speech-Language-Hearing Association
Nov2021
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=153519495&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 153519495 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10924388 1SM jtl: Journal of Speech, Language & Hearing Research issn: 10924388 maglogo: N pubinfo: dt: Nov2021 vid: 64 iid: 11 pid: 42 pub: American Speech-Language-Hearing Association artinfo: ui: 153519495 10.1044/2021_JSLHR-21-00038 ppf: 4178 ppct: 14 formats: fmt: @attributes: type: P size: 1.4MB tig: atl: Psychometric Properties of Rapid Word-Based Rate Measures in the Assessment of Bulbar Amyotrophic Lateral Sclerosis: Comparisons With Syllable-Based Rate Tasks. aug: au: Shellikeri, Sanjana Marzouqah, Reeman Brooks, Benjamin Rix Zinman, Lorne Green, Jordan R. Yunusova, Yana affil: Penn Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania, Philadelphia Department of Speech-Language Pathology, Rehabilitation Sciences Institute, University of Toronto, Ontario, Canada Department of Neurology, Carolinas Medical Center, Carolinas Neuromuscular/ALS-MDA Care Center Atrium Health Neurosciences Institute, University of North Carolina, Charlotte Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada LC Campbell Cognitive Neurology Research Group, Sunnybrook Research Institute, University of Toronto, Ontario, Canada Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Toronto Rehabilitation Institute (KITE), University Health Network, Ontario, Canada su: Psychometrics Task performance Vocabulary Tempo (Phonetics) Amyotrophic lateral sclerosis Articulation (Speech) Syllable (Grammar) Repetition (Learning process) Speech perception Disease progression Research evaluation Progressive bulbar palsy Research methodology evaluation Research methodology Intelligibility of speech Tongue Comparative studies Multitrait multimethod techniques Medical protocols Descriptive statistics Receiver operating characteristic curves Kinematics Longitudinal method Symptoms sug: subj: Psychometrics Task performance Vocabulary Tempo (Phonetics) Amyotrophic lateral sclerosis Articulation (Speech) Syllable (Grammar) Repetition (Learning process) Speech perception Disease progression Research evaluation Progressive bulbar palsy Research methodology evaluation Research methodology Intelligibility of speech Tongue Comparative studies Multitrait multimethod techniques Medical protocols Descriptive statistics Receiver operating characteristic curves Kinematics Longitudinal method Symptoms ab: Purpose: Rapid maximum performance repetition tasks have increasingly demonstrated their utility as clinimetric markers supporting diagnosis and monitoring of bulbar disease in amyotrophic lateral sclerosis (ALS). A recently developed protocol uses novel real-word repetitions instead of traditional nonword/syllable sequences in hopes of improving sensitivity to motor speech impairments by adding a phonological target constraint that would activate a greater expanse of the motor speech neuroanatomy. This study established the psychometric properties of this novel clinimetric protocol in its assessment of bulbar ALS and compared performance to traditional syllable sequence dysdiadochokinetic (DDK) tasks. Specific objectives were to (a) compare rates between controls and speakers with symptomatic versus presymptomatic bulbar disease, (b) characterize their discriminatory ability in detecting presymptomatic bulbar disease compared to healthy speech, (c) determine their articulatory movement underpinnings, and (d) establish within-individual longitudinal changes. Method: DDK and novel tongue ("ticker"--TAR) and labial ("pepper"--LAR) articulatory rates were compared between n = 18 speakers with presymptomatic bulbar disease, n = 10 speakers with symptomatic bulbar disease, and n = 13 healthy controls. Bulbar disease groups were determined by a previously validated speaking rate cutoff. Discriminatory ability was determined using receiver operating characteristic analysis. Within-individual change over time was characterized in a subset of 16 participants with available longitudinal data using linear mixed-effects models. Real-time articulatory movements of the tongue front, tongue dorsum, jaw, and lips were captured using 3-D electromagnetic articulography; effects of movement displacement and speed on clinimetric rates were determined using stepwise linear regressions. Results: All clinimetric rates (traditional DDK tasks and novel tasks) were reduced in speakers with symptomatic bulbar disease; only TAR was reduced in speakers with presymptomatic bulbar disease and was able to detect this group with an excellent discrimination ability (area under the curve = 0.83). Kinematic analyses revealed associations with expected articulators, greater motor complexity, and differential articulatory patterns for the novel real-word repetitions than their DDK counterparts. Only LAR significantly declined longitudinally over the disease course. Conclusion: Novel real-word clinimetric rate tasks evaluating tongue and labial articulatory dysfunction are valid and effective markers for early detection and tracking of bulbar disease in ALS. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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