Brain functional correlates of formal thought disorder in schizophrenia: examining the frontal/dysexecutive hypothesis.
Background: One hypothesis proposed to underlie formal thought disorder (FTD), the incoherent speech is seen in some patients with schizophrenia, is that it reflects impairment in frontal/executive function. While this proposal has received support in neuropsychological studies, it has been relative...
| Publicado en: | Psychological Medicine Vol. 51; no. 14; pp. 2446 - 2454 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Oct2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153538058&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153538058 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Oct2021 vid: 51 iid: 14 pid: 15979 pub: Cambridge University Press artinfo: ui: 153538058 153538058 153538058 10.1017/S0033291720001063 153538058 ppf: 2446 ppct: 8 formats: tig: atl: Brain functional correlates of formal thought disorder in schizophrenia: examining the frontal/dysexecutive hypothesis. aug: au: Fuentes-Claramonte, P. López-Araquistain, L. Sarró, S. Sans-Sansa, B. Ortiz-Gil, J. Maristany, T. Salvador, R. McKenna, P.J. Pomarol-Clotet, E. affil: FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain sug: subj: Brain Physiology Speech Disorders Schizophrenia Physiopathology Executive Function Memory, Short Term Task Performance and Analysis Human Matched Case Control Magnetic Resonance Imaging Methods Thalamus Physiology Basal Ganglia Physiology Female Male Adult Middle Age Aged Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Background: One hypothesis proposed to underlie formal thought disorder (FTD), the incoherent speech is seen in some patients with schizophrenia, is that it reflects impairment in frontal/executive function. While this proposal has received support in neuropsychological studies, it has been relatively little tested using functional imaging. This study aimed to examine brain activations associated with FTD, and its two main factor-analytically derived subsyndromes, during the performance of a working memory task. Methods: Seventy patients with schizophrenia showing a full range of FTD scores and 70 matched healthy controls underwent fMRI during the performance of the 2-back version of the n-back task. Whole-brain corrected, voxel-based correlations with FTD scores were examined in the patient group. Results: During 2-back performance the patients showed clusters of significant inverse correlation with FTD scores in the inferior frontal cortex and dorsolateral prefrontal cortex bilaterally, the left temporal cortex and subcortically in the basal ganglia and thalamus. Further analysis revealed that these correlations reflected an association only with 'alogia' (poverty of speech, poverty of content of speech and perseveration) and not with the 'fluent disorganization' component of FTD. Conclusions: This study provides functional imaging support for the view that FTD in schizophrenia may involve impaired executive/frontal function. However, the relationship appears to be exclusively with alogia and not with the variables contributing to fluent disorganization. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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