Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial.
Background: The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of thes...
| Publicado en: | Nutrition Journal Vol. 20; no. 1; pp. 1 - 15 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
11/13/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153552015&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153552015 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14752891 1CYY jtl: Nutrition Journal issn: 14752891 maglogo: N pubinfo: dt: 11/13/2021 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 153552015 153552015 NLM34774052 153552015 10.1186/s12937-021-00748-8 NLM34774052 153552015 ppf: 1 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial. aug: au: Uchio, Ryusei Kawasaki, Kengo Okuda-Hanafusa, Chinatsu Saji, Ryosuke Muroyama, Koutarou Murosaki, Shinji Yamamoto, Yoshihiro Hirose, Yoshitaka affil: Research & Development Institute, House Wellness Foods Corp., 3-20 Imoji, 664-0011, Itami, Hyogo, Japan sug: subj: Plants Mental Health Obesity Drug Therapy Human Research Subjects Plant Extracts Comparative Studies Multicenter Studies Evaluation Research Validation Studies Short Form-36 Health Survey (SF-36) Questionnaires ab: Background: The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health.Methods: We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05).Results: After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score (p < 0.05).Conclusion: CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance.Trial Registration: UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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