Brain functional and structural characteristics of patients with seizure recurrence following drug withdrawal.
Purpose: We aimed to analyze the characteristics of brain function and microstructure linked to epilepsy relapse after drug withdrawal in patients with focal epilepsy. Methods: Resting-state functional magnetic resonance imaging and high-resolution T1-weighted images were acquired within 1 month pri...
| Publicado en: | Neuroradiology Vol. 63; no. 12; pp. 2087 - 2098 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153556620&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153556620 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Dec2021 vid: 63 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 153556620 153556620 153556620 10.1007/s00234-021-02755-2 153556620 ppf: 2087 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Brain functional and structural characteristics of patients with seizure recurrence following drug withdrawal. aug: au: Tan, Ge Li, Xiuli Chen, Deng Wang, Haijiao Gong, Qiyong Liu, Ling affil: From the Epilepsy Center, Department of Neurology, West China Hospital, Sichuan University, No. 37, Guoxue Road, 610041, Chengdu, Sichuan Province, China sug: subj: Epilepsy Pathology Recurrence Brain Physiology Brain Anatomy and Histology Epilepsy Drug Therapy Treatment Termination Human Magnetic Resonance Imaging Methods Correlational Studies Image Processing, Computer Assisted Descriptive Statistics Neuroradiography Methods Polypharmacy Anticonvulsants Adverse Effects Heterocyclic Compounds Adverse Effects Disease Duration Biological Markers ab: Purpose: We aimed to analyze the characteristics of brain function and microstructure linked to epilepsy relapse after drug withdrawal in patients with focal epilepsy. Methods: Resting-state functional magnetic resonance imaging and high-resolution T1-weighted images were acquired within 1 month prior to drug withdrawal from 15 patients who did not have epilepsy relapse (PER − group) and 16 patients who subsequently had epilepsy relapse (PER + group). Additionally, 23 healthy participants undergoing the same scanning protocol were included as controls. Fractional amplitude of low-frequency fluctuation (fALFF) and gray matter density (GMD) were compared among groups. Subgroup and correlation analyses were also performed. Results: There were no significant differences in fALFF between patient groups, but the PER + group showed lower GMD in the bilateral calcarine, left precuneus, and right superior temporal gyrus than the PER − group (Gaussian random field correction, voxel-level P < 0.001 and cluster-level P < 0.05). Both increased seizure number and polytherapy were associated with lower GMD; also, patients using other antiseizure medications showed lower GMD than those using only levetiracetam (Gaussian random field correction, voxel-level P < 0.001, and cluster-level P < 0.05). The active period and disease duration showed both positive and negative correlations with GMD, while the seizure-free period mainly showed positive correlations with GMD (uncorrected, P < 0.001). Conclusion: Gray matter microstructure, but not local functional activity, showed distinct characteristics between patients with and without epilepsy relapse and may serve as a potential biomarker for predicting seizure recurrence upon drug withdrawal. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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