Diagnostic Value of TI-RADS Classification System and Next Generation Genetic Sequencing in Indeterminate Thyroid Nodules.
Rationale and Objectives: This study aims to evaluate the diagnostic accuracy, inter-reader, and intra-reader variability of the ACR Thyroid Imaging Reporting and Data System (TI-RADS) for risk-stratification of indeterminate thyroid nodules using next generation genetic sequencing and tissue histol...
| Publicado en: | Academic Radiology Vol. 28; no. 12; pp. 1685 - 1692 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Dec2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153581338&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153581338 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10766332 T4X jtl: Academic Radiology issn: 10766332 maglogo: N pubinfo: dt: Dec2021 vid: 28 iid: 12 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 153581338 153581338 NLM32839097 153581338 10.1016/j.acra.2020.07.037 NLM32839097 153581338 ppf: 1685 ppct: 7 formats: tig: atl: Diagnostic Value of TI-RADS Classification System and Next Generation Genetic Sequencing in Indeterminate Thyroid Nodules. aug: au: Daniels, Kelly E. Xu, Jiajun Liu, Ji-Bin Chen, Xiangmei Huang, Kun Patel, Jena Cottrill, Elizabeth Eisenbrey, John R. Lyshchik, Andrej affil: Thomas Jefferson University, Department of Otolaryngology – Head & Neck Surgery, Philadelphia Pennsylvania sug: subj: Thyroid Nodule Retrospective Design Female Middle Age Adult Aged Ultrasonography Reproducibility of Results Arthritis Impact Measurement Scales Psychological Tests Human Middle Aged: 45-64 years Adult: 19-44 years Aged: 65+ years Female ab: Rationale and Objectives: This study aims to evaluate the diagnostic accuracy, inter-reader, and intra-reader variability of the ACR Thyroid Imaging Reporting and Data System (TI-RADS) for risk-stratification of indeterminate thyroid nodules using next generation genetic sequencing and tissue histology as a reference standard.Materials and Methods: Retrospective chart review was performed on all patients who underwent thyroid ultrasound for a nodule with subsequent fine-needle aspiration ± surgical resection from January 2017 to August 2018. Four radiologists with expertise in thyroid ultrasound assessed imaging twice, ≥1 month apart. Results of cytology and next generation genetic sequencing were used as a reference standard for high versus low risk of malignancy in each nodule. Inter-reader reliability between readers and intra-reader reliability between replicate self-reads for TI-RADS categorization were assessed. Univariate analysis, kappa statistics, and receiver operating characteristic curve were calculated.Results: One hundred and thirty six nodules across 121 patients met inclusion criteria. 84.6% of patients were female and average age was 55.8 ± 14.1 years. One hundred and eighteen of 135 nodules (87%) had indeterminate cytology (Bethesda III or IV). One of 23 high-risk mutations was identified in 30.1% (42) of the nodules. Of the 52 patients who had surgery, 24 (47.1%) had confirmed malignant disease on surgical pathology. Inter-reader reliability between the four radiologists was marginal, κ = 0.293. Intra-reader reliability ranged from marginal to good, κ = 0.337 to κ = 0.560, respectively. The area under the receiver operating characteristic curve was 0.509, and no optimal TI-RADS Level for identifying high-risk nodules existed.Conclusion: The ACR TI-RADS classification system performs with low inter-reader and intra-reader reliability when assessing the genetic risk of nodules with indeterminate cytology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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