Two new prenylated coumarins from roots of Zanthoxylum nitidum.
Two new prenylated coumarins, 3'-hydroxytoddanone (1), and isotoddalolactone (2), along with four known analogues (3–6) were isolated from the roots of Zanthoxylum nitidum. Their chemical structures were elucidated based on extensive spectroscopic interpretation and HR-ESI-MS analysis. The absolute...
| Publicado en: | Journal of Asian Natural Products Research Vol. 23; no. 11; pp. 1043 - 1051 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov 2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153608273&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153608273 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10286020 J40 jtl: Journal of Asian Natural Products Research issn: 10286020 maglogo: Y pubinfo: dt: Nov 2021 vid: 23 iid: 11 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 153608273 153258582 153608273 153608273 10.1080/10286020.2021.1993835 153608273 ppf: 1043 ppct: 8 formats: tig: atl: Two new prenylated coumarins from roots of Zanthoxylum nitidum. aug: au: Niu, Sheng-Li Lv, Tian-Meng Tong, Zhi-Fan Li, Xin-Yu Xue, Jing-Jing Yuan, Jing Hu, Ping affil: Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110016, China sug: subj: Plants, Medicinal Plant Roots Analysis Plant Extracts Analysis Phytochemicals Analysis Benzopyrans Analysis Benzopyrans Analogs and Derivatives Biochemical Phenomena Molecular Structure Evaluation Antineoplastic Agents Analysis Antineoplastic Agents Pharmacodynamics Plant Extracts Pharmacodynamics Benzopyrans Pharmacodynamics Leukemia Drug Therapy Plants Funding Source Electrospray Ionization Mass Spectrometry Magnetic Resonance Spectroscopy Nuclear Physics In Vitro Studies Cell Proliferation Drug Effects Cell Line, Tumor Drug Effects Growth Inhibitors Pharmacodynamics Descriptive Statistics Comparative Studies Spectrophotometry Spectrophotometers Chromatography Methods Data Analysis Software Bioinformatics ab: Two new prenylated coumarins, 3'-hydroxytoddanone (1), and isotoddalolactone (2), along with four known analogues (3–6) were isolated from the roots of Zanthoxylum nitidum. Their chemical structures were elucidated based on extensive spectroscopic interpretation and HR-ESI-MS analysis. The absolute configuration of compound 2 was determined by comparing experimental ECD spectrum with that calculated by the time-dependent density functional theory (TDDFT) method. Compounds 4–6 were isolated from the Zanthoxylum genus for the first time. The two new compounds were tested for antiproliferative activities in vitro on the HL-60, K562 and THP-1 cell lines. Compounds 1 and 2 exhibited moderate cell growth inhibitory activities in vitro against human leukemic HL-60 cell lines, with IC50 values of 32.64 and 33.15 µM, respectively. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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