Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project.
Objective: It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatmen...
| Publicado en: | Cancer Control: Journal of the Moffitt Cancer Center Vol. 28; pp. 1 - 12 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Sage Publications Inc.
11/18/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153654791&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153654791 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10732748 1CJM jtl: Cancer Control: Journal of the Moffitt Cancer Center issn: 10732748 maglogo: Y pubinfo: dt: 11/18/2021 vid: 28 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 153654791 153654791 NLM34789006 10.1177/10732748211038429 NLM34789006 153654791 ppf: 1 ppct: 11 formats: tig: atl: Clinicopathological Variables and Outcome in Chronic Myeloid Leukemia Associated With BCR-ABL1 Transcript Type and Body Weight: An Outcome of European LeukemiaNet Project. aug: au: Abdulla, Mohammad A. J. Chandra, Prem Akiki, Susanna El Aldapt, Mahmood B. Sardar, Sundus Chapra, Ammar Nashwan, Abdulqadir J. Sorio, Claudio Tomasello, Luisa Boni, Christian Yassin, Mohamed A. affil: Department of Medical Oncology, Hematology Section, National Center for Cancer Care and Research, 36977 Hamad Medical Corporation, Doha, Qatar sug: ab: Objective: It is debatable whether BCR-ABL1 transcript type has an impact on outcome of treatment of patients with CML, and it is not widely studied whether body weight influences response to treatment. In this study, we tried to find out if any of these factors has an impact on response to treatment and outcome.Methodology: We conducted a retrospective analysis of the files of 79 patients being treated in our center for CML with known BCR-ABL1 breakpoints, and patients' management and response assessment was done based on ELN 2013 guidelines. The analysis was performed based on two main groups, obese vs. normal BMI, and then based on BCR-ABL1 transcripts: e13a2 vs. e14a2. Cumulative incidence of MMR, CCyR, and DMR were estimated using the Kaplan-Meier survival curve method, and comparisons between groups were performed by the Log-rank/Gray test methods.Results/conclusion: In the patient-cohort studied, there was no statistically significant difference in molecular response between patients with CML based on body weight or transcript type although patients in the obesity group achieved higher and faster MMR with no statistical significance. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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