Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects.
Background: Impulsivity is more commonly reported in subjects with mental disorders compared to healthy subjects, suggesting a potential application of impulsivity in predicting impulsivity-related mental disorders. However, no biomarker of impulsivity available so far. This study explored the assoc...
| Publicado en: | BMC Neuroscience Vol. 22; no. 1; pp. 1 - 10 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
11/20/2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153680774&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153680774 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712202 1CI8 jtl: BMC Neuroscience issn: 14712202 maglogo: N pubinfo: dt: 11/20/2021 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 153680774 153680774 NLM34800969 153680774 10.1186/s12868-021-00676-7 NLM34800969 153680774 ppf: 1 ppct: 9 formats: tig: atl: Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects. aug: au: Xu, Jinzhong Wu, Fenzan Li, Yuying Wang, Fan Lin, Wenhui Qian, Song Li, Hui Fan, Yuncao Li, Huai Chen, Lijing Xu, Haiyun Chen, Li Liu, Yanlong Li, Xiaokun He, Jue affil: Department of Clinical Pharmacy, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, Zhejiang, China sug: subj: Serotonin Metabolism Growth Substances Metabolism Behavior Dopamine Metabolism Male Young Adult Research Subjects Statistics and Numerical Data Adolescence Middle Age Female Mental Disorders Physiopathology Adult Human Psychological Tests Statistics and Numerical Data Comparative Studies Multicenter Studies Evaluation Research Validation Studies Scales Adolescent: 13-18 years Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Background: Impulsivity is more commonly reported in subjects with mental disorders compared to healthy subjects, suggesting a potential application of impulsivity in predicting impulsivity-related mental disorders. However, no biomarker of impulsivity available so far. This study explored the association between cerebrospinal fluid (CSF) fibroblast growth factor 21 (FGF21), a key hormonal mediator of the stress response, and impulsivity in healthy subjects.Methods: A total of 126 healthy persons subjected to surgery of anterior cruciate ligament were recruited in the present study. The impulsiveness of the subjects was evaluated by the Chinese version of the Barratt Impulsiveness Scale (BIS)-11 before surgery. CSF and blood samples of the subjects were collected before spinal anesthesia for surgery. The levels of FGF21, serotonin and dopamine in CSF and the level of FGF21 in blood of the subjects were measured by ELISA using commercial kits.Results: Negative correlations were found between BIS-11 total score and either FGF21, serotonin or dopamine in CSF. However, BIS-11 total score was not correlated with FGF21 in blood. In addition, FGF21 was positively correlated with serotonin and dopamine in CSF, respectively. Multivariable linear regression models indicated that the decrease of FGF21 level associating with the decrease of serotonin and dopamine level in CSF contributed to the higher impulsivity. Furthermore, receiver operating characteristic curve (ROC) analysis indicated an important role of CSF FGF21 predicting high impulsivity.Conclusions: FGF21, serotonin and dopamine in CSF associate with impulsivity in opposite directions. The decrease of CSF FGF21 is related to higher impulsivity, and indicate that CSF FGF21 may predict impulsivity in healthy subjects. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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