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Lymphomatoid papulosis in a patient treated with glatiramer acetate and the glatiramoid Glatopa for multiple sclerosis: A case report.

A 48-year-old Caucasian woman with history of multiple sclerosis (MS) presented with erythematous papulonodular lesions in her extremities and trunk. She was being treated with glatiramer acetate (GA) for the past 10 years and the glatiramoid, Glatopa, for 2 years prior to this presentation. A skin...

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Published in:Journal of Central Nervous System Disease pp. 1 - 4
Main Authors: Shirani, Afsaneh, Dalton, Scott R, Avery, Eric J, Arcot Jayagopal, Lakshman, Meyer, Christina, Stuve, Olaf, Zabad, Rana
Format: case study pictorial Journal Article
Published: Sage Publications Inc. 11/20/2021
Online Access:View this record in EBSCOhost
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      dt: 11/20/2021
      pid: 344
      pub: Sage Publications Inc.
      place: Thousand Oaks, California
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        10.1177/11795735211053784
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        atl: Lymphomatoid papulosis in a patient treated with glatiramer acetate and the glatiramoid Glatopa for multiple sclerosis: A case report.
      aug:
        au:
          Shirani, Afsaneh
          Dalton, Scott R
          Avery, Eric J
          Arcot Jayagopal, Lakshman
          Meyer, Christina
          Stuve, Olaf
          Zabad, Rana
        affil: Department of Neurological Sciences, 12284 University of Nebraska Medical Center, Omaha, NE, USA
      sug:
        subj:
          Lymphoproliferative Disorders Diagnosis
          Skin Diseases, Papulosquamous Diagnosis
          Precancerous Conditions Diagnosis
          Extremities Pathology
          Torso Pathology
          Multiple Sclerosis Drug Therapy
          Immunosuppressive Agents Adverse Effects
          Skin Diseases, Papulosquamous Pathology
          Precancerous Conditions Pathology
          Lymphoproliferative Disorders Pathology
          Middle Age
          Female
          Lichenoid Eruptions Diagnosis
          Pityriasis Diagnosis
          Biopsy
          Drug Tapering
          Natalizumab Therapeutic Use
          Lymphoproliferative Disorders Chemically Induced
          Skin Diseases, Papulosquamous Chemically Induced
          Lichenoid Eruptions Chemically Induced
          Pityriasis Chemically Induced
          Middle Aged: 45-64 years
          Female
      ab: A 48-year-old Caucasian woman with history of multiple sclerosis (MS) presented with erythematous papulonodular lesions in her extremities and trunk. She was being treated with glatiramer acetate (GA) for the past 10 years and the glatiramoid, Glatopa, for 2 years prior to this presentation. A skin biopsy showed CD30+ lymphoproliferative disorder consistent with lymphomatoid papulosis (LyP). Three weeks after stopping Glatopa, her skin lesions were improved. It remains unclear whether GA's or Glatopa's capability to alter T-cell differentiation, may have a link with LyP. This case report is a reminder to be vigilant for skin lesions in patients with MS.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        Journal Article
      ougenre: Article
    language: English
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