Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl.
The phytochemical investigation of the methanolic extracts of roots, stem bark, leaves and twigs of Manilkara obovata has led to the isolation of one new friedelane triterpene, lacefriedelic acid or 3β,23-dihydroxy D:A-friedooleanan-28-oic acid (1) and one new prenylated xanthone, lacexanthone or 4,...
| Published in: | Natural Product Research Vol. 35; no. 22; pp. 4347 - 4357 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Taylor & Francis Ltd
Nov 2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153688742&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153688742 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Nov 2021 vid: 35 iid: 22 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 153688742 145605393 10.1080/14786419.2020.1713123 153688742 ppf: 4347 ppct: 10 formats: tig: atl: Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. aug: au: Akosung, Emmanuel Kenmogne, Sidonie Beactrice Lobe Songue, Jules Longue Ekon, Jean Pierre Lateef, Mehreen Ngeufa Happi, Emmanuel Langat, Moses Kiprotich Tabekoueng, Georges Bellier Toze, Flavien Aristide Alfred Stammler, Hans-Georg Ndjakou Lenta, Bruno Wansi, Jean Duplex Sewald, Norbert Ali, Muhammad Shaiq Kamdem Waffo, Alain François affil: Faculty of Sciences, Chemistry Laboratory, University of Douala, Douala, Cameroon sug: ab: The phytochemical investigation of the methanolic extracts of roots, stem bark, leaves and twigs of Manilkara obovata has led to the isolation of one new friedelane triterpene, lacefriedelic acid or 3β,23-dihydroxy D:A-friedooleanan-28-oic acid (1) and one new prenylated xanthone, lacexanthone or 4,7-dihydroxy-2,3,3,9,9-pentamethyl-2,2-dihydrofurano[2,3-a]pyrano[2,3-i]xanthen-13(9H)-one (2) alongside twenty-four known compounds. Compounds 1-11 are reported here for the first time from the genus Manilkara. The structures of all compounds were determined by spectroscopic analyses and X-ray crystallography. The methanolic extracts of twigs and leaves showed anti-oxidant activity of 93.2 and 91.1%, respectively, at 100 µg/mL when measured by DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate), while the twig extract displayed 86.3% at 100 µg/mL against the urease inhibition assay. Some isolated compounds (1-4, 15 and 20) showed significant to moderate anti-oxidant activity and urease inhibition assay. It is estimated that significantly active anti-oxidants and urease inhibitors metabolized by the plant may find future application in food industry. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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