Nicotine preference and affective behavior of Cd81 knockout mice.
Rationale: Cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine turnover, but normal learning and memory in the Morris water maze. The effects of Cd81 on other behaviors and drugs of abuse have not been investi...
| Publicado en: | Psychopharmacology Vol. 238; no. 12; pp. 3477 - 3498 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153848270&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153848270 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Dec2021 vid: 238 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 153848270 152308649 10.1007/s00213-021-05966-w 153848270 ppf: 3477 ppct: 21 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Nicotine preference and affective behavior of Cd81 knockout mice. aug: au: Murphy, R. Logan Locklear, Laura L. Niaz, M. Haris Walton, Rebecca L. Hudson, Alexandra D. Fryxell, Karl J. affil: School of Systems Biology, and the Interdisciplinary Program in Neurosciences, George Mason University, Mail Stop 1J1, Institute of Advanced Biomedical Research Building, 10920 George Mason Circle, 20110, Manassas, VA, USA sug: ab: Rationale: Cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine turnover, but normal learning and memory in the Morris water maze. The effects of Cd81 on other behaviors and drugs of abuse have not been investigated. Objectives and methods: We measured the effects of Cd81 -/- in a modified two-bottle choice test for nicotine, as well as in somatic signs of nicotine withdrawal, four tests of affective behavior, and tyrosine hydroxylase gene expression assays. Results: We found that Cd81 loss-of-function significantly increased voluntary nicotine consumption and somatic signs of nicotine withdrawal. Nicotine consumption of Cd81 -/- female mice increased for 3 weeks and then remained relatively stable for the next 5 weeks, suggesting that their nicotine consumption continued to be limited by aversion to higher nicotine doses. Cd81 -/- also produced a dramatic and significant increase in struggling in the forced swim test and a significant increase in the time spent in the light chamber of the light/dark box. The elevated plus maze and the tail suspension test did not show a main effect of genotype. Therefore, we conclude that Cd81 did not have an overall effect on anxiety- or depression-like behavior. Tyrosine hydroxylase mRNA levels were unchanged. Conclusions: Cd81 knockouts have a strongly increased nicotine preference, plus a proactive response to specific stressful situations. Together with reports of increased striatal dopamine content and anecdotal reports of increased aggressiveness, these provide intriguing parallels to some aspects of post-traumatic stress disorder. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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