In vitro α-glycosidase and urease enzyme inhibition profile of some selected medicinal plants of Pakistan.
The current study aims at exploring enzyme inhibition of four species of medicinal herbs, namely Senna bicapsularis, Thevetia peruviana, Nerium oleander and Vinca major. Plant selection was done on the basis of their therapeutic uses by local practitioners. The crude methanolic extracts of these pla...
| Publicado en: | Natural Product Research Vol. 35; no. 23; pp. 5434 - 5440 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec 2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=153878865&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 153878865 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14786419 RFT jtl: Natural Product Research issn: 14786419 maglogo: Y pubinfo: dt: Dec 2021 vid: 35 iid: 23 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 153878865 145587299 10.1080/14786419.2020.1779264 153878865 ppf: 5434 ppct: 6 formats: tig: atl: In vitro α-glycosidase and urease enzyme inhibition profile of some selected medicinal plants of Pakistan. aug: au: Rauf, Abdur Bawazeer, Saud Naseer, Muhammad Alhumaydhi, Fahad A. Aljohani, Abdullah S. M. Habib, Aamir Khan, Raheem Jehan, Urooj Qureshi, Muhammad Nasimullah Khan, Majid Farooq, Umar Kassenov, Amirzhan Shariati, Mohammad Ali affil: Department of Chemistry, University of Swabi, Swabi, Pakistan sug: ab: The current study aims at exploring enzyme inhibition of four species of medicinal herbs, namely Senna bicapsularis, Thevetia peruviana, Nerium oleander and Vinca major. Plant selection was done on the basis of their therapeutic uses by local practitioners. The crude methanolic extracts of these plants were tested for their α-glycosidase and urease enzyme inhibition potential. The observed urease inhibitory potential for the crude extract of S. bicapsularis, T. peruviana and N. oleander were 8.3 ± 0.33 μg, 6.98 ± 0.98 μg and 9.56 ± 1.43 μg, respectively while the V. major did not show any inhibition. In addition, the IC50 value for Thiourea was 22.3 ± 1.14 μg. The crude extracts of S. bicapsularis, T. peruviana, N. oleander, V. major were shown to inhibit α-glycosidase activity with an IC50 value of 630.3 ± 0.03 μg, 700.7 ± 2.43 μg, 430.4 ± 3.97 μg, and the standard (acarbose) 880 ± 1.03 μM, respectively. Based on the TLC profile, the extract of S. bicapsularis was subjected to column chromatography and the major component named rhein (1) was identified. Compound 1 exhibited excellent urease and α-glycosidase inhibitory activity with an IC50 value of 7.4 ± 0.32 and 622.3 ± 1.03 μM, respectively. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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