Consensus recommendation on the use of therapeutic plasma exchange for adult neurological diseases in Southeast Asia from the Southeast Asia therapeutic plasma exchange consortium.

Therapeutic plasma exchange (TPE) is an effective and affordable treatment option in most parts of Southeast Asia (SEA). In 2018, the SEA TPE Consortium (SEATPEC) was established, consisting of regional neurologists working to improve outcome of various autoimmune neurological diseases. We proposed...

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Published in:Journal of Central Nervous System Disease pp. 1 - 13
Main Authors: Hiew, Fu Liong, Thit, Win Min, Alexander, Mathew, Thirugnanam, Umapathi, Siritho, Sasitorn, Tan, Kevin, Mya Aye, Seinn Mya, Ohnmar, Ohnmar, Estiasari, Riwanti, Yassin, Norazieda, Pasco, Paul Matthew, Keosodsay, Say Saysavath, Trong Nghia, Hoang Tien, Islam, MD Badrul, Wong, Sing Keat, Lee, Shirley, Chhabra, Anupam, Viswanathan, Shanthi
Format: standards Journal Article
Published: Sage Publications Inc. 11/25/2021
Online Access:View this record in EBSCOhost
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      dt: 11/25/2021
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      pub: Sage Publications Inc.
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        atl: Consensus recommendation on the use of therapeutic plasma exchange for adult neurological diseases in Southeast Asia from the Southeast Asia therapeutic plasma exchange consortium.
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          Hiew, Fu Liong
          Thit, Win Min
          Alexander, Mathew
          Thirugnanam, Umapathi
          Siritho, Sasitorn
          Tan, Kevin
          Mya Aye, Seinn Mya
          Ohnmar, Ohnmar
          Estiasari, Riwanti
          Yassin, Norazieda
          Pasco, Paul Matthew
          Keosodsay, Say Saysavath
          Trong Nghia, Hoang Tien
          Islam, MD Badrul
          Wong, Sing Keat
          Lee, Shirley
          Chhabra, Anupam
          Viswanathan, Shanthi
        affil: Department of Neurology, 58983 Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
      sug:
        subj:
          Nervous System Diseases Therapy
          Plasma Exchange Asia, Southeastern
          Adult
          Plasmapheresis
          Collaboration
          Guideline Adherence
          Immunotherapy
          Asia, Southeastern
          Adult: 19-44 years
      ab: Therapeutic plasma exchange (TPE) is an effective and affordable treatment option in most parts of Southeast Asia (SEA). In 2018, the SEA TPE Consortium (SEATPEC) was established, consisting of regional neurologists working to improve outcome of various autoimmune neurological diseases. We proposed an immunotherapeutic guideline prioritizing TPE for this region. We reviewed disease burden, evidence-based treatment options, and major guidelines for common autoimmune neurological disorders seen in SEA. A modified treatment algorithm based on consensus agreement by key-opinion leaders was proposed. Autoimmune antibody diagnostic testing through collaboration with accredited laboratories was established. Choice of first-line immunotherapies (IVIg/corticosteroid/TPE) is based on available evidence, clinicians' experience, contraindications, local availability, and affordability. TPE could be chosen as first-line therapy for GBS, CIDP, MG (acute/short term), IgG, A paraproteinemic neuropathy, and NMDAR encephalitis. Treatment is stopped for acute monophasic conditions such as GBS and ADEM following satisfactory outcome. For chronic immune disorders, a therapy taper or long-term maintenance therapy is recommended depending on the defined clinical state. TPE as second-line treatment is indicated for IVIg or corticosteroids refractory cases of ADEM, NMOSD (acute), MG, and NMDAR/LGI1/CASPR2/Hashimoto's encephalitis. With better diagnosis, treatment initiation with TPE is a sustainable and effective immunotherapy for autoimmune neurological diseases in SEA.
      pubtype: Academic Journal
      doctype:
        standards
        Journal Article
      ougenre: Article
    language: English
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