Does Intravenous Ondansetron Reduces the Incidence of Post-spinal Shivering in Obstetric Population? A Double Blind, Prospective Randomised, Control Study...Malaysian Society of Anaesthesiologists & College of Anaesthesiologists, AMM, Annual Scientific Congress August 6-8, 2021 (Virtual)
Objective: Caesarean section under subarachnoid block (SAB) is often associated with shivering. Although shivering may have beneficial thermoregulatory effect, perioperative shivering is an unfavourable event as it places the body under increased physiological stress. Ondansetron, a 5-HT3 antagonist...
| Published in: | Medicine & Health (Universiti Kebangsaan Malaysia) Vol. 16; pp. 31 - 32 |
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| Main Authors: | , , , , |
| Format: | abstract proceedings research randomized controlled trial Journal Article |
| Published: |
Universiti Kebangsaan Malaysia, Faculty of Medicine
2021 Supplement
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154082958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154082958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22895728 AZ6D jtl: Medicine & Health (Universiti Kebangsaan Malaysia) issn: 22895728 maglogo: N pubinfo: dt: 2021 Supplement vid: 16 pid: 78060 pub: Universiti Kebangsaan Malaysia, Faculty of Medicine artinfo: ui: 154082958 154082958 154082958 154082958 ppf: 31 ppct: 1 formats: tig: atl: Does Intravenous Ondansetron Reduces the Incidence of Post-spinal Shivering in Obstetric Population? A Double Blind, Prospective Randomised, Control Study...Malaysian Society of Anaesthesiologists & College of Anaesthesiologists, AMM, Annual Scientific Congress August 6-8, 2021 (Virtual) aug: au: TX TEOH JAUHARATUNNUR ISHAK SM LIM CHAW SH CAROLYN CW YIM affil: Department of Anaesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia sug: subj: Cesarean Section Methods Anesthesia, Spinal Adverse Effects Shivering Drug Effects Ondansetron Pharmacodynamics Perioperative Care Methods Ondansetron Administration and Dosage Administration, Intravenous Drug Efficacy Evaluation Congresses and Conferences Randomized Controlled Trials Obstetric Patients ab: Objective: Caesarean section under subarachnoid block (SAB) is often associated with shivering. Although shivering may have beneficial thermoregulatory effect, perioperative shivering is an unfavourable event as it places the body under increased physiological stress. Ondansetron, a 5-HT3 antagonist is a commonly used antiemetic during pregnancy and perioperatively to treat post-operative nausea and vomiting (PONV). Previous studies showed promising results on reducing post-spinal shivering. The objective of this study is to establish the efficacy of IV Ondansetron 4 mg in reducing the incidence of post-spinal shivering in our local population. Methods: In this double-blind study, 120 patients of MRCOG grade 2-4 LSCS under subarachnoid block (SAB) were recruited and randomised equally into Group O (received IV Ondansetron 4 mg/2mls) and Group P (received IV NaCl 0.9% 2 mls) before SAB. Shivering assessment were performed immediately after SAB and every 30 minutes and severity graded on scale of 0-4, 4 being generalized vigorous shivering. Patients with shivering grade 3-4 was treated with IV pethidine and total dose required documented. Body temperature trend throughout the duration in the operation theatre (OT) was recorded while the OT temperature maintained constant at a range of 16-22°C. Incidence of PONV throughout operation and postoperatively was also documented. Results: Group O has a statistically significant lower incidence of post-spinal shivering compared to Group P (16, 26.7% vs 30, 50%; P=0.009). Group O required less IV pethidine for shivering treatment. Group O also reported a statistically significant lower incidence of PONV compared to Group P. The body temperature trend throughout the duration in OT does not show statistical difference between Group O and Group P at various time point. Conclusion: IV Ondansetron 4 mg is effective in preventing post-spinal shivering in parturient and reduces the need of IV pethidine to treat post-spinal shivering. IV Ondansetron 4mg is also effective in preventing PONV for parturient. pubtype: Academic Journal doctype: abstract proceedings research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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