Mathematical and Computational Models for Pain: A Systematic Review.

Objective There is no single prevailing theory of pain that explains its origin, qualities, and alleviation. Although many studies have investigated various molecular targets for pain management, few have attempted to examine the etiology or working mechanisms of pain through mathematical or computa...

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Publicado en:Pain Medicine Vol. 22; no. 12; pp. 2806 - 2818
Autores principales: Lang, Victoria Ashley, Lundh, Torbjörn, Ortiz-Catalan, Max
Formato: algorithm research systematic review tables/charts Journal Article
Publicado: Oxford University Press / USA Dec2021
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2021
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      pub: Oxford University Press / USA
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        10.1093/pm/pnab177
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        atl: Mathematical and Computational Models for Pain: A Systematic Review.
      aug:
        au:
          Lang, Victoria Ashley
          Lundh, Torbjörn
          Ortiz-Catalan, Max
        affil: Center for Bionics and Pain Research , Sweden
      sug:
        subj:
          Pain Measurement Methods
          Pain Management Methods
          Mathematics
          Computing Methodologies
          Human
          Systematic Review
          Pain Etiology
          PubMed
      ab: Objective There is no single prevailing theory of pain that explains its origin, qualities, and alleviation. Although many studies have investigated various molecular targets for pain management, few have attempted to examine the etiology or working mechanisms of pain through mathematical or computational model development. In this systematic review, we identified and classified mathematical and computational models for characterizing pain. Methods The databases queried were Science Direct and PubMed , yielding 560 articles published prior to January 1st, 2020. After screening for inclusion of mathematical or computational models of pain, 31 articles were deemed relevant. Results Most of the reviewed articles utilized classification algorithms to categorize pain and no-pain conditions. We found the literature heavily focused on the application of existing models or machine learning algorithms to identify the presence or absence of pain, rather than to explore features of pain that may be used for diagnostics and treatment. Conclusions Although understudied, the development of mathematical models may augment the current understanding of pain by providing directions for testable hypotheses of its underlying mechanisms. Additional focus is needed on developing models that seek to understand the underlying mechanisms of pain, as this could potentially lead to major breakthroughs in its treatment.
      pubtype: Academic Journal
      doctype:
        algorithm
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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