Co-Occurrence of Hypernasality and Voice Impairment in Amyotrophic Lateral Sclerosis: Acoustic Quantification.
Purpose: Hypernasality and atypical voice characteristics are common features of dysarthric speech due to amyotrophic lateral sclerosis (ALS). Existing acoustic measures have been developed to primarily target either hypernasality or voice impairment, and the effects of co-occurring hypernasality-vo...
| Publicado en: | Journal of Speech, Language & Hearing Research Vol. 64; no. 12; pp. 4772 - 4784 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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American Speech-Language-Hearing Association
Dec2021
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=154172446&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 154172446 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10924388 1SM jtl: Journal of Speech, Language & Hearing Research issn: 10924388 maglogo: N pubinfo: dt: Dec2021 vid: 64 iid: 12 pid: 42 pub: American Speech-Language-Hearing Association artinfo: ui: 154172446 10.1044/2021_JSLHR-21-00123 ppf: 4772 ppct: 12 formats: fmt: @attributes: type: P size: 691KB tig: atl: Co-Occurrence of Hypernasality and Voice Impairment in Amyotrophic Lateral Sclerosis: Acoustic Quantification. aug: au: Eshghi, Marziye Connaghan, Kathryn P. Gutz, Sarah E. Berry, James D. Yunusova, Yana Green, Jordan R. affil: Speech and Feeding Disorders Lab, MGH Institute of Health Professions, Boston, MA Program in Speech and Hearing Bioscience and Technology, Harvard University, Boston, MA Sean M. Healey and AMG Center for ALS, Department of Neurology, Massachusetts General Hospital, Boston Department of Speech-Language Pathology, Rehabilitation Sciences Institute, University of Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Toronto Rehabilitation Institute (KITE), University Health Network, Ontario, Canada su: Disease risk factors Hypernasality Human voice Amyotrophic lateral sclerosis Acoustic measurements Dysarthria Sentences (Grammar) Voice disorders Kruskal-Wallis Test Statistics Physiological aspects of speech Predictive tests Speech evaluation Mann Whitney U Test Severity of illness index Inter-observer reliability Descriptive statistics Intraclass correlation Research funding Data analysis Receiver operating characteristic curves Disease complications sug: subj: Disease risk factors Hypernasality Human voice Amyotrophic lateral sclerosis Acoustic measurements Dysarthria Sentences (Grammar) Voice disorders Kruskal-Wallis Test Statistics Physiological aspects of speech Predictive tests Speech evaluation Mann Whitney U Test Severity of illness index Inter-observer reliability Descriptive statistics Intraclass correlation Research funding Data analysis Receiver operating characteristic curves Disease complications ab: Purpose: Hypernasality and atypical voice characteristics are common features of dysarthric speech due to amyotrophic lateral sclerosis (ALS). Existing acoustic measures have been developed to primarily target either hypernasality or voice impairment, and the effects of co-occurring hypernasality-voice problems on these measures are unknown. This report explores (a) the extent to which acoustic measures are affected by concurrent perceptually identified hypernasality and voice impairment due to ALS and (b) candidate acoustic measures of early indicators of hypernasality and voice impairment in the presence of multisystem involvement in individuals with ALS. Method: Two expert listeners rated severity of hypernasality and voice impairment in sentences produced by individuals with ALS (n = 27). The samples were stratified based on perceptual ratings: voice/hypernasality asymptomatic, predominantly hypernasal, predominantly voice impairment, and mixed (co-occurring hypernasality and voice impairment). Groups were compared using established acoustic measures of hypernasality (one-third octave analysis) and voice (cepstral/spectral analysis) impairment. Results: The one-third octave analysis differentiated all groups; the cepstral peak prominence differentiated all groups except asymptomatic versus mixed, whereas the low-to-high spectral ratio did not differ among groups. Additionally, one-third octave analyses demonstrated promising speech diagnostic potential. Conclusions: The results highlight the need to consider the validity of measures in the context of multisubsystem involvement. Our preliminary findings further suggest that the one-third octave analysis may be an optimal approach to quantify hypernasality and voice abnormalities in the presence of multisystem speech impairment. Future evaluation of the diagnostic accuracy of the onethird octave analysis is warranted. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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