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Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis.

Introduction: The platelet count/spleen diameter (PC/SD) ratio is a noninvasive method for the diagnosis of esophageal varices (EV) used as an alternative to endoscopy in patients with cirrhosis. Objective: To evaluate the diagnostic performance of the PC/SD ratio (cut-off point <909) to detect EV i...

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Published in:Revista Facultad de Medicina de la Universidad Nacional de Colombia Vol. 69; no. 3; pp. 1 - 6
Main Authors: David Martínez-Marín, Julián, Marrugo-Padilla, Katherine, Alonso Garzón-Olarte, Martín
Format: Article
Published: Universidad Nacional de Colombia jul-sep2021
Subjects:
PLATELET count
ESOPHAGEAL varices
CIRRHOSIS of the liver
PERSONAL computer performance
AUTOIMMUNE hepatitis
SPLEEN
Online Access:View this record in EBSCOhost
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      dt: jul-sep2021
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      pub: Universidad Nacional de Colombia
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        10.15446/revfacmed.v69n3.78786
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        atl: Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis.
      aug:
        au:
          David Martínez-Marín, Julián
          Marrugo-Padilla, Katherine
          Alonso Garzón-Olarte, Martín
        affil:
          Universidad Nacional de Colombia - Bogotá Campus - Faculty of Medicine - Department of Gastroenterology - Bogotá D.C. - Colombia
          Hospital Universitario de La Samaritana Empresa Social del Estado - Gastroenterology Service - Bogotá D.C. - Colombia
          Universidad del Rosario - School of Health Sciences - Department of Gastroenterology - Bogotá D.C. - Colombia
      su:
        PLATELET count
        ESOPHAGEAL varices
        CIRRHOSIS of the liver
        PERSONAL computer performance
        AUTOIMMUNE hepatitis
        SPLEEN
      sug:
        subj:
          PLATELET count
          ESOPHAGEAL varices
          CIRRHOSIS of the liver
          PERSONAL computer performance
          AUTOIMMUNE hepatitis
          SPLEEN
      keyword:
        Esophageal Varices
        Liver Cirrhosis
        Platelet Count
        Cirrosis hepática
        Recuento de plaquetas
        Varices esofágicas
      ab:
        Introduction: The platelet count/spleen diameter (PC/SD) ratio is a noninvasive method for the diagnosis of esophageal varices (EV) used as an alternative to endoscopy in patients with cirrhosis. Objective: To evaluate the diagnostic performance of the PC/SD ratio (cut-off point <909) to detect EV in patients with cirrhosis treated at a tertiary referral hospital in Bogotá D.C., Colombia. Materials and methods: A prospective diagnostic test accuracy study was conducted in 66 patients with cirrhosis treated at the Hospital Universitario de La Samaritana between July and December 2018. A descriptive analysis of the data was performed. In addition, the diagnostic performance of the PC/SD ratio (cut-off point <909) for the detection of EV was compared with the findings reported in the esophagogastroduodenoscopy (gold standard), calculating its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-). A significance level of p<0.05 was considered. Results: The mean age of the participants was 65.5 years, 53.03% were female, and the most common causes of cirrhosis were alcohol consumption (40.90%) and autoimmune hepatitis (22.72%). EV was diagnosed in 48 patients (72.72%). The PC/SC ratio showed sensitivity of 60%, specificity of 78%, PPV of 0.88, NPV of 0.42, LR+ of 2.73, and LR- of 0.51. Conclusion: The low sensitivity, specificity, and NPV found in the present study suggest that the PC/SD ratio (cut-off point <909) may not be a useful diagnostic test for detecting EV in patients with cirrhosis.
        Introducción. El índice de recuento de plaquetas/diámetro del bazo (RP/DB) es un método no invasivo para el diagnóstico de varices esofágicas (VE) que se usa como alternativa a la endoscopia en pacientes con cirrosis. Objetivo. Evaluar el rendimiento diagnóstico del índice RP/DM (punto de corte <909) para detectar VE en pacientes cirróticos atendidos en un hospital de tercer nivel de Bogotá D.C., Colombia. Materiales y métodos. Estudio prospectivo de validez de prueba diagnóstica realizado en 66 pacientes cirróticos atendidos en el Hospital Universitario de La Samaritana entre julio y diciembre de 2018. Se realizó un análisis descriptivo de los datos. Además, el rendimiento diagnóstico del índice RP/DM (punto de corte <909) para la detección de VE se comparó con los hallazgos de la esofagogastroduodenoscopia (prueba de oro), calculándose su sensibilidad, especificidad, valor predictivo positivo (VPP), valor predictivo negativo (VPN), razón de probabilidad positiva (LR+) y razón de probabilidad negativa (LR-). Se consideró un nivel de significancia de p<0.05. Resultados. La edad promedio de los participantes fue 65.5 años, 53.03% eran mujeres y las causas más comunes de cirrosis fueron consumo de alcohol (40.90%) y hepatitis autoinmune (22.72%). Las VE fueron diagnosticadas en 48 pacientes (72.72%). El índice RP/DM tuvo una sensibilidad de 60%, una especificidad de 78%, un VPP de 0.88, un VPN de 0.42, una LR+ de 2.73 y una LR- de 0.51. Conclusión. La baja sensibilidad, especificidad y VPN encontrados en el presente estudio sugieren que el índice RP/DM (punto de corte <909) podría no ser una prueba diagnóstica útil para detectar VE en pacientes cirróticos.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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