Study on mechanism of cerebral blood flow and cognitive impairment related to white matter hyperintensity.
Objective To explore the relationship between alteration of cerebral blood flow (CBF) and cognitive impairment in patients with white matter hyperintensity (WMH). Methods Eighty patients with WMH and 37 controls matching sex, age and education were enrolled. Patients with WMH were divided into mild...
| Published in: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 21; no. 12; pp. 1064 - 1073 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Chinese Journal of Contemporary Neurology & Neurosurgery
Dec2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154383989&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154383989 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: Dec2021 vid: 21 iid: 12 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 154383989 154383989 154383989 10.3969/j.issn.1672-6731.2021.12.007 154383989 ppf: 1064 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Study on mechanism of cerebral blood flow and cognitive impairment related to white matter hyperintensity. aug: au: LIU Yuan-yuan CAO Shan-shan HU Pan-pan TIAN Yang-hua WANG Kai WEI Qiang affil: Department of Neurology, The First Affiliated Hospital of Anhui Medical University; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders; Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei 230022, Anhui, China sug: subj: Cerebrovascular Circulation Cognition Disorders Risk Factors Cognition Disorders Physiopathology White Matter Pathology Risk Assessment Human Comparative Studies Scales Neuropsychological Tests Cognition Evaluation Magnetic Resonance Imaging Pearson's Correlation Coefficient Correlation Coefficient Descriptive Statistics Cerebral Small Vessel Diseases Complications ab: Objective To explore the relationship between alteration of cerebral blood flow (CBF) and cognitive impairment in patients with white matter hyperintensity (WMH). Methods Eighty patients with WMH and 37 controls matching sex, age and education were enrolled. Patients with WMH were divided into mild WMH group (n = 33, Fazekas score 1-2) and moderate-severe WMH group (n = 47, Fazekas score 3-6). Montreal Cognitive Assessment (MoCA), Chinese Auditory Verbal Learning Test (CAVLT), Symbol Digit Modalities Test (SDMT), Color Trail Test (CTT) and Boston Naming Test (BNT) were respectively used to assess overall cognitive function, memory, attention, executive function and language. The 3D-pseudo-continuous arterial spin labeling (3D-pCASL) was used to assess CBF. The relationship between CBF and cognitive function was estimated by Pearson correlation and partial correlation analyses. Results 1) MoCA (F = 3.433, P = 0.036), CAVLT-study (F = 4.123, P = 0.019), CAVLT-immediate (F = 7.929, P = 0.001), CAVLT-delay (F = 6.738, P = 0.002), CAVLT- recognition (F = 5.762, P = 0.004), SDMT (F = 5.136, P = 0.008), CTT-A (F = 7.155, P = 0.001) and BNT (F = 4.329, P = 0.032) were statistically significant among 3 groups. The moderate-severe WMH group was less than control group in MoCA (t = 2.525, P = 0.013), CAVLT- study (t = 2.683, P = 0.009), CAVLT- immediate (t = 3.593, P = 0.004), CAVLT- delay (t = 3.497, P = 0.001), CAVLT-recognition (t = 3.264, P = 0.002), SDMT (t = 3.170, P = 0.002), BNT (t = 2.584, P = 0.011) as well as less than the mild WMH group in CAVLT-study (t = 2.025, P = 0.046), CAVLT- immediate (t = 3.033, P = 0.003), CAVLT-delay (t = 2.458, P = 0.016) and CAVLT-recognition (t = 2.181, P = 0.032), while more than control group in CTT-A (t =-3.668, P = 0.000). The mild WMH group was more than control group in CTT-A (t =-2.697, P = 0.008). 2) The CBF of right putamen, left putamen and right median cingulate were statistically significant among 3 groups [Gaussian random field (GRF) corrected, cluster P < 0.05, voxel P < 0.001]. Compared to control group and the mild WMH group, the CBF of the right putamen (t = 5.039, P = 0.000; t = 3.672, P = 0.000), the left putamen (t = 5.808, P = 0.000; t = 2.665, P = 0.009) and right median cingulate (t = 5.038, P = 0.000; t = 3.319, P = 0.001) were more in the moderate - severe WMH group. Compared to the control group, the CBF of the right median cingulate was higher in the mild WMH group (t = 1.476, P = 0.006). 3) The correlation analysis showed that in the mild WMH group, the CBF of the right putamen was positively correlated with SDMT (r = 0.478, P = 0.028), and negatively correlated with CTT-A (r =-0.483, P = 0.026), the CBF of left putamen was positively correlated with MoCA (r = 0.451, P = 0.040), and negatively correlated with CTT-A (r =-0.502, P = 0.020), the CBF of right median cingulate was positively correlated with MoCA (r = 0.446, P = 0.043); in the moderate-severe WMH group, the CBF of the right putamen was positively correlated with CAVLT-recognition (r = 0.343, P = 0.043). Conclusions The alteration of CBF in the brain may be a possible neuropathological mechanism of WMH and relate to cognitive impairment in WMH. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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