Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives.
CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising fou...
| Published in: | Current Oncology Vol. 28; no. 6; pp. 4972 - 4986 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Published: |
MDPI
Dec2021
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154401423&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154401423 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Dec2021 vid: 28 iid: 6 pid: 97109 pub: MDPI artinfo: ui: 154401423 10.3390/curroncol28060417 154401423 ppf: 4972 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Potential Role of CCN Proteins in Breast Cancer: Therapeutic Advances and Perspectives. aug: au: Ahmed, Kazi Ahsan Al Hasib, Tasnin Paul, Shamrat Kumar Saddam, Md. Mimi, Afsana Saikat, Abu Saim Mohammad Al Faruque, Hasan Rahman, Md. Ataur Uddin, Md. Jamal Kim, Bonglee affil: ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh sug: ab: CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising four distinct modules. CCN Proteins achieve their primary functional activities by binding with several integrin7 receptors. The CCN family has been linked to cell adhesion, chemotaxis and migration, mitogenesis, cell survival, angiogenesis, differentiation, tumorigenesis, chondrogenesis, and wound healing, among other biological interactions. Breast cancer is the most commonly diagnosed cancer worldwide and CCN regulated breast cancer stands at the top. A favorable or unfavorable association between various CCNs has been reported in patients with breast carcinomas. The pro-tumorigenic CCN1, CCN2, CCN3, and CCN4 may lead to human breast cancer, although the anti-tumorigenic actions of CCN5 and CCN6 are also present. Several studies have been conducted on CCN proteins and cancer in recent years. CCN1 and CCN3 have been shown to exhibit a dual nature of tumor inhibition and tumor suppression to some extent in quiet recent time. Pharmacological advances in treating breast cancer by targeting CCN proteins are also reported. In our study, we intend to provide an overview of these research works while keeping breast cancer in focus. This information may facilitate early diagnosis, early prognosis and the development of new therapeutic strategies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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