Methanolic Extract of Muntingia Calabura L. Mitigates 1,2-Dimethyl Hydrazine Induced Colon Carcinogenesis in Wistar Rats.
The present study aimed to evaluate the efficacy of methanolic extract of Muntingia calabura L. leaves (MEMC) in ameliorating oxidative stress and inflammation associated with 1,2-dimethyl hydrazine (DMH) induced colon cancer. The antioxidant enzymes, oxidative stress markers, liver and renal toxici...
| Publicado en: | Nutrition & Cancer Vol. 73; no. 11/12; pp. 2363 - 2376 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2021
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154439033&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154439033 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2021 vid: 73 iid: 11/12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 154439033 146070591 154439033 154439033 10.1080/01635581.2020.1823438 154439033 ppf: 2363 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Methanolic Extract of Muntingia Calabura L. Mitigates 1,2-Dimethyl Hydrazine Induced Colon Carcinogenesis in Wistar Rats. aug: au: Jisha, Ninan Vysakh, A. Vijeesh, V. Anand, P. S. Latha, M. S. affil: School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India sug: subj: Colonic Neoplasms Chemically Induced Plant Extracts Pharmacodynamics Colonic Neoplasms Drug Therapy Plant Leaves Pharmacodynamics Inflammation Prevention and Control Oxidative Stress Drug Effects Carcinogens Adverse Effects Animal Studies Rats Colonic Neoplasms Physiopathology Antioxidants Biological Markers Histology Staining and Labeling Plant Extracts Administration and Dosage Severity of Illness ab: The present study aimed to evaluate the efficacy of methanolic extract of Muntingia calabura L. leaves (MEMC) in ameliorating oxidative stress and inflammation associated with 1,2-dimethyl hydrazine (DMH) induced colon cancer. The antioxidant enzymes, oxidative stress markers, liver and renal toxicity markers were evaluated. Histopathological examination of colon tissues was carried out with the aid of alcian blue stain and Hematoxylin and Eosin stain. MEMC supplementation at doses of 100 and 200 mg/kg body weight of rats causes the antioxidant enzymic levels to retain near to its normal range. Meanwhile the oxidative stress markers, which showed an elevation from its normal level upon DMH administration, gets significantly reduced on MEMC treatment. Histopathological observation also revealed that the severity of colorectal cancer was reduced by the supplementation of MEMC. The findings from the present study showed that MEMC can exert a potential role to ameliorate the oxidative stress and inflammation associated with colorectal cancer. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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