Structural and functional brain connectivity in moderate–late preterm infants with low-grade intraventricular hemorrhage.
Purpose: Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on brain structural connectivity (SC) and FC. Meth...
| Publicado en: | Neuroradiology Vol. 64; no. 1; pp. 197 - 205 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154457837&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154457837 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jan2022 vid: 64 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 154457837 151715906 154457837 154457837 10.1007/s00234-021-02770-3 154457837 ppf: 197 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural and functional brain connectivity in moderate–late preterm infants with low-grade intraventricular hemorrhage. aug: au: Argyropoulou, Maria I. Xydis, Vasileios G. Drougia, Aikaterini Giantsouli, Anastasia S. Giapros, Vasileios Astrakas, Loukas G. affil: Department of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, P.O. Box 1186, 45110, Ioannina, Greece sug: subj: Cerebral Hemorrhage Pathology Brain Pathology Functional Connectivity Evaluation Brain Ultrasonography Infant, Premature Magnetic Resonance Imaging Neuroradiography Human Infant, Newborn Gestational Age Comparative Studies Descriptive Statistics Infant, Newborn: birth-1 month ab: Purpose: Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on brain structural connectivity (SC) and FC. Methods: Babies born MLPT between January 2014 and May 2017 underwent brain ultrasound (US) at 72 h and 7 days after birth, and MRI at around term equivalent. The MRI protocol comprised T1- and T2-weighted sequences, diffusion tensor imaging (DTI), and resting-state functional MRI (fMRI). SC and FC were assessed using graph analysis. Results: Of 350 MLPT neonates, 15 showed low-grade IVH on US at 72 h, for which brain MRI was available in 10. These 10 infants, with mean gestational age (GA) 34.0 ± 0.8 weeks, comprised the study group, and 10 MLPT infants of mean GA 33.9 ± 1.1 weeks, with no abnormalities on brain US and MRI, were control subjects. All study subjects presented modularity, small world topology, and rich club organization for both SC and FC. The patients with low-grade IVH had lower FC rich club coefficient and lower SC betweenness centrality in the left frontoparietal operculum, and lower SC rich club coefficient in the right superior orbitofrontal cortex than the control subjects. Conclusions: Topological and functional properties of mature brain connectivity are present in MLPT infants. IVH in these infants was associated with structural and functional abnormalities in the left frontoparietal operculum and right orbitofrontal cortex, regions related to language and cognition. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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