In silico evaluation of limited sampling strategies for individualized dosing of extended half-life factor IX concentrates in hemophilia B patients.

Purpose: Hemophilia B is a bleeding disorder, caused by a factor IX (FIX) deficiency. Recently, FIX concentrates with extended half-life (EHL) have become available. Prophylactic dosing of EHL-FIX concentrates can be optimized by assessment of individual pharmacokinetic (PK) parameters. To determine...

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Publicado en:	European Journal of Clinical Pharmacology Vol. 78; no. 2; pp. 237 - 250
Autores principales:	Preijers, T., van Spengler, M. W. F., Meijer, K., Fijnvandraat, K., Fischer, K., Leebeek, F. W. G., Cnossen, M. H., Mathôt, R. A. A.
Formato:	equations & formulas research tables/charts Journal Article
Publicado:	Springer Nature Feb2022
Acceso en línea:	Ver este registro en EBSCOhost