| Sumario: | Objectives: Online learning has been applied to replace normal classroom of universities around the globe due to the COVID 19 pandemic. The purpose of this study was to compare the effectiveness of online and in-class learning in a nursing lecture course, and to survey the students' and instructors' satisfaction regarding online learning. Methods: The comparative study was used. The sample consisted of277 students enrolled in the course between 2019 and 2021, and 6 instructors who taught both courses. Of the students, 141 were in-class students while 136 were online students. The effectiveness was measured using learning achievement score. The online learning satisfaction of students and instructors were collected at the end of the semester. Data were analyzed using independent t-tests and descriptive statistics. Results: There is no significant difference in learning achievement between online and in-class learning (p>.05). However, the mean course evaluation score of the two groups were found to differ with statistical significance (p<.05). Students' satisfaction level was lower than that of instructors. Students were nevertheless highly satisfied with 'provided instructional material' of the course design. Conclusion: The findings suggest that well-designed online course can provide the online learners with the same efficacy of normal classroom students.
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