Parametric Approaches in Population Pharmacokinetics.
Population pharmacokinetic (popPK) approaches have spread widely throughout clinical pharmacology research, and every clinician should have some understanding of them. After a general introduction on the fundamentals and fields of application of these approaches, this review focuses on parametric po...
| Publicado en: | Journal of Clinical Pharmacology Vol. 62; no. 2; pp. 125 - 142 |
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| Autores principales: | , , |
| Formato: | equations & formulas review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154795647&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154795647 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00912700 5WH jtl: Journal of Clinical Pharmacology issn: 00912700 maglogo: Y pubinfo: dt: Feb2022 vid: 62 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 154795647 146595470 154795647 154795647 10.1002/jcph.1633 154795647 ppf: 125 ppct: 17 formats: tig: atl: Parametric Approaches in Population Pharmacokinetics. aug: au: Guidi, Monia Csajka, Chantal Buclin, Thierry affil: Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland sug: subj: Pharmacy and Pharmacology Drug Development Pharmacokinetics Algorithms Software Data Analysis Simulations Drug Monitoring Efavirenz ab: Population pharmacokinetic (popPK) approaches have spread widely throughout clinical pharmacology research, and every clinician should have some understanding of them. After a general introduction on the fundamentals and fields of application of these approaches, this review focuses on parametric popPK methods to provide the clinicians with the conceptual tools to interpret appropriately the results of parametric popPK analyses and to understand their clinical utility. The emphasis is put on the clinical questions that popPK methods are best suited to address. The basic principles of the methodology are introduced first, and then the main algorithms and reference software programs used in such analyses are presented. The description of data analysis and clinical applications of the parametric popPK approach (ie, use in simulations and therapeutic drug monitoring) are illustrated with the example of the antiretroviral drug efavirenz. pubtype: Academic Journal doctype: equations & formulas review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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