Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.

Objectives: Systemic sclerosis (SSc) is a complex disease of unknown aetiology in which inflammation and fibrosis lead to multiple organ damage. There is currently no effective therapy that can halt the progression of fibrosis or reverse it, thus studies that provide novel insights into disease path...

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Publicado en:	Annals of the Rheumatic Diseases Vol. 81; no. 2; pp. 268 - 278
Autores principales:	Malaab, Maya, Renaud, Ludivine, Takamura, Naoko, Zimmerman, Kip D., da Silveira, Willian A., Ramos, Paula S., Haddad, Sandra, Peters-Golden, Marc, Penke, Loka R., Wolf, Bethany, Hardiman, Gary, Langefeld, Carl D., Medsger, Thomas A., Feghali-Bostwick, Carol A.
Formato:	research Journal Article
Publicado:	Elsevier B.V. Feb2022
Acceso en línea:	Ver este registro en EBSCOhost