A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action
Purpose: Cereboost®, an American ginseng extract, has shown improved short-term memory and attention/alertness in healthy young and middle-aged individuals, potentially via modulation of the gut microbiome and upregulation of neurotransmitters such as acetylcholine. Here, we explored the effects of...
| Publicado en: | European Journal of Nutrition Vol. 61; no. 1; pp. 413 - 429 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154815066&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154815066 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2022 vid: 61 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 154815066 151910142 154815066 154815066 10.1007/s00394-021-02654-5 154815066 ppf: 413 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action aug: au: Bell, Lynne Whyte, Adrian Duysburgh, Cindy Marzorati, Massimo Van den Abbeele, Pieter Le Cozannet, Romain Fança-Berthon, Pascale Fromentin, Emilie Williams, Claire affil: School of Psychology & Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights Road, RG6 6ES, Reading, UK sug: subj: Ginseng Pharmacodynamics Ginseng Pharmacodynamics Affect Drug Effects Cognition Drug Effects Gut Microbiota Drug Effects Ginseng Administration and Dosage Dietary Supplementation Postprandial Period Treatment Duration Dose-Response Relationship, Drug Evaluation Human In Vitro Studies Randomized Controlled Trials Double-Blind Studies Placebos Administration and Dosage Memory, Short Term Drug Effects Attention Drug Effects Comparative Studies Reaction Time Drug Effects Acetylcholine Task Performance and Analysis Mental Fatigue Prevention and Control Acetic Acid Drug Effects Propionates Drug Effects Butyric Acids Drug Effects Colon Drug Effects Lactobacillus Drug Effects Fatty Acids, Volatile Drug Effects Adolescence Young Adult Adolescent: 13-18 years ab: Purpose: Cereboost®, an American ginseng extract, has shown improved short-term memory and attention/alertness in healthy young and middle-aged individuals, potentially via modulation of the gut microbiome and upregulation of neurotransmitters such as acetylcholine. Here, we explored the effects of Cereboost® on cognition and mood in the first 6 h post intervention (acute), after 2 weeks daily supplementation (chronic), and whether 2 weeks daily supplementation altered the response to a single acute dose (acute-on-chronic). A concurrent in vitro study evaluated effects of repeated Cereboost® administration on human gut microbiota. Methods: Cognitive effects of Cereboost® were assessed using a double-blind, randomized, placebo-controlled clinical trial, with 61 healthy young adults. Modulation of the gut microbiome was concurrently modelled using the Simulator of the Human Microbial Ecosystem (SHIME®), using a young adult donor. Results: Consistent with previous findings, Cereboost® improved working memory and attention during the immediate postprandial period; effects that were amplified following two weeks' treatment (acute-on-chronic) compared to acute testing alone. Chronic supplementation improved cognition on an acetylcholine-sensitive attention task and improved mental fatigue and self-assurance aspects of mood. The parallel in vitro study revealed significantly increased acetate, propionate, and butyrate levels in simulated proximal and distal colon regions, linked with observed increases in Akkermansia muciniphila and Lactobacillus. Conclusion: This study confirmed the promising effects of Cereboost® on cognitive function and mood, while suggesting a possible link to alterations of the gut microbiome and modulation of acetylcholine. Further studies will be required to unravel the underlying mechanisms that are involved. Registration: The study was pre-registered at ClinicalTrials.gov on 6th July 2018 (Identifier: NCT03579095). pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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