Management Strategies for Older Patients with Low-Risk Early-Stage Breast Cancer: A Physician Survey.
When managing older patients with lower-risk hormone-receptor-positive (HR+), HER2 negative (HER2−) early-stage breast cancer (EBC), the harms and benefits of adjuvant therapies should be taken into consideration. A survey was conducted among Canadian oncologists on the definitions of "low risk" and...
| Publicado en: | Current Oncology Vol. 29; no. 1; pp. 1 - 14 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154815145&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154815145 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Feb2022 vid: 29 iid: 1 pid: 97109 pub: MDPI artinfo: ui: 154815145 154815145 154815145 10.3390/curroncol29010001 154815145 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Management Strategies for Older Patients with Low-Risk Early-Stage Breast Cancer: A Physician Survey. aug: au: Alzahrani, Mashari Clemons, Mark Chang, Lynn Vendermeer, Lisa Arnaout, Angel Larocque, Gail Cole, Katherine Hsu, Tina Saunders, Deanna Savard, Marie-France affil: Department of Medicine, Division of Medical Oncology, The Ottawa Hospital and The University of Ottawa, Ottawa, ON K1H 8L6, Canada sug: subj: Breast Neoplasms Rehabilitation Neoplasm Staging Management Methods Strategic Planning Methods Human Aged Aged, 80 and Over Oncologists Canada Canada Lumpectomy Breast Neoplasms Radiotherapy Endocrine Diseases Therapy Disease-Free Survival Quality of Life Aged: 65+ years Aged, 80 & over ab: When managing older patients with lower-risk hormone-receptor-positive (HR+), HER2 negative (HER2−) early-stage breast cancer (EBC), the harms and benefits of adjuvant therapies should be taken into consideration. A survey was conducted among Canadian oncologists on the definitions of "low risk" and "older", practice patterns, and future trial designs. We contacted 254 physicians and 21% completed the survey (50/242). Most respondents (68%, 34/50) agreed with the definition of "low risk" HR+/HER2− EBC being node-negative and either: ≤3 cm and low histological grade, ≤2 cm and intermediate grade, or ≤1 cm and high grade. The most popular chronological and biological age definition for older patients was ≥70 (45%, 22/49; 45% 21/47). In patients ≥ 70 with low risk EBC, most radiation and medical oncologists would recommend post-lumpectomy radiotherapy (RT) and endocrine therapy (ET). Seventy-eight percent (38/49) felt that trials are needed to evaluate RT and ET's role in patients ≥ 70. The favored design was ET alone, vs. RT plus ET (39%, 15/38). The preferred primary and secondary endpoints were disease-free survival and quality of life, respectively. Although oncologists recommended both RT and ET, there is interest in performing de-escalation trials in patients ≥ 70. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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