Treatment of Older Adult Patients with Glioblastoma: Moving towards the Inclusion of a Comprehensive Geriatric Assessment for Guiding Management.
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, and over half of patients with newly diagnosed GBM are over the age of 65. Management of glioblastoma in older patients includes maximal safe resection followed by either radiation, chemotherapy, or combined modality trea...
| Publicado en: | Current Oncology Vol. 29; no. 1; pp. 360 - 377 |
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| Autores principales: | , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
MDPI
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154815176&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154815176 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Feb2022 vid: 29 iid: 1 pid: 97109 pub: MDPI artinfo: ui: 154815176 154815176 154815176 10.3390/curroncol29010032 154815176 ppf: 360 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Treatment of Older Adult Patients with Glioblastoma: Moving towards the Inclusion of a Comprehensive Geriatric Assessment for Guiding Management. aug: au: Chahal, Manik Thiessen, Brian Mariano, Caroline affil: Division of Medical Oncology, British Columbia Cancer-Vancouver Cancer Centre, Vancouver, BC V5Z 4E6, Canada sug: subj: Glioma Therapy Geriatric Assessment Aged Glioma Surgery Glioma Radiotherapy Glioma Drug Therapy Chemoradiotherapy Chemoradiotherapy, Adjuvant Decision Making, Clinical Combined Modality Therapy Aged: 65+ years ab: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, and over half of patients with newly diagnosed GBM are over the age of 65. Management of glioblastoma in older patients includes maximal safe resection followed by either radiation, chemotherapy, or combined modality treatment. Despite recent advances in the treatment of older patients with GBM, survival is still only approximately 9 months compared to approximately 15 months for the general adult population, suggesting that further research is required to optimize management in the older population. The Comprehensive Geriatric Assessment (CGA) has been shown to have a prognostic and predictive role in the management of older patients with other cancers, and domains of the CGA have demonstrated an association with outcomes in GBM in retrospective studies. Furthermore, the CGA and other geriatric assessment tools are now starting to be prospectively investigated in older GBM populations. This review aims to outline current treatment strategies for older patients with GBM, explore the rationale for inclusion of geriatric assessment in GBM management, and highlight recent data investigating its implementation into practice. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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