Divergent effects of oxytocin on "mind-reading" in healthy males.
The neuropeptide oxytocin (OT) has been associated with a broad range of human behaviors, particularly in the domain of social cognition, and is being discussed to play a role in a range of psychiatric disorders. Studies using the Reading The Mind In The Eyes Test (RMET) to investigate the role of O...
| Published in: | Cognitive, Affective & Behavioral Neuroscience Vol. 22; no. 1; pp. 112 - 123 |
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| Main Authors: | , , , , , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Springer Nature
Feb2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154881095&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154881095 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Feb2022 vid: 22 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 154881095 152434359 154881095 154881095 10.3758/s13415-021-00936-3 154881095 ppf: 112 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Divergent effects of oxytocin on "mind-reading" in healthy males. aug: au: Macchia, Ana Zebhauser, Paul Theo Salcedo, Stephanie Burum, Bethany Gold, Edward Alonso-Alonso, Miguel Pascual-Leone, Alvaro Gilbert, Daniel Brem, Anna-Katharine affil: Max Planck Institute of Psychiatry, Munich, Germany sug: subj: Oxytocin Blood Theory of Mind Men Oxytocin Metabolism Human Male Social Cognition Evaluation Psychological Tests Descriptive Statistics Confidence Intervals Probability Serum Analysis Administration, Intranasal Oxytocin Administration and Dosage Randomized Controlled Trials Double-Blind Studies Crossover Design Male ab: The neuropeptide oxytocin (OT) has been associated with a broad range of human behaviors, particularly in the domain of social cognition, and is being discussed to play a role in a range of psychiatric disorders. Studies using the Reading The Mind In The Eyes Test (RMET) to investigate the role of OT in mental state recognition reported inconsistent outcomes. The present study applied a randomized, double-blind, cross-over design, and included measures of serum OT. Twenty healthy males received intranasal placebo or OT (24 IU) before performing the RMET. Frequentist and Bayesian analyses showed that contrary to previous studies (Domes et al., 2007; Radke & de Bruijn, 2015), individuals performed worse in the OT condition compared to the placebo condition (p = 0.023, Cohen's d = 0.55, 95% confidence interval [CI] [0.08, 1.02], BF10 = 6.93). OT effects did not depend on item characteristics (difficulty, valence, intensity, sex) of the RMET. Furthermore, OT serum levels did not change after intranasal OT administration. Given that similar study designs lead to heterogeneous outcomes, our results highlight the complexity of OT effects and support evidence that OT might even interfere with social cognitive abilities. However, the Bayesian analysis approach shows that there is only moderate evidence that OT influences mind-reading, highlighting the need for larger-scale studies considering the discussed aspects that might have led to divergent study results. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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