The Neural Circuitry of Reward During Sustained Threat.
Reward processing is important for understanding behavior in psychopathology. Opportunities to earn money activate the ventral striatum, as shown by the monetary incentive delay (MID) task. Anxiety conditions have been modeled by presenting shocks and startling sounds. To further investigate the co-...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 22; no. 1; pp. 134 - 145 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154881097&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154881097 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Feb2022 vid: 22 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 154881097 152073689 154881097 154881097 10.3758/s13415-021-00938-1 154881097 ppf: 134 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Neural Circuitry of Reward During Sustained Threat. aug: au: Penner, Anne E. White, Emma Stoddard, Joel Gowin, Joshua L. affil: Department of Psychiatry, University of Colorado, Anschutz Medical Campus, 80045, Aurora, CO, USA sug: subj: Nervous System Physiology Neural Pathways Brain Physiology Reward Human Female Male Cues Questionnaires Magnetic Resonance Imaging T-Tests Descriptive Statistics Multiple Linear Regression Female Male ab: Reward processing is important for understanding behavior in psychopathology. Opportunities to earn money activate the ventral striatum, as shown by the monetary incentive delay (MID) task. Anxiety conditions have been modeled by presenting shocks and startling sounds. To further investigate the co-occurrence of an anxiety condition and a rewarding stimulus, we modified the MID to include a sustained threat of scream. This study investigated neural patterns of the MID task with an uncertain threat of a startling scream. Forty-three young adults completed a functional MRI scan. The task included two conditions (scream and safe) and three cues (gain $5, gain $0, lose $5). Analyses included a whole brain, group analysis using a linear mixed-effects model and a paired t-test. The whole brain analysis revealed a main effect of cue, with increased ventral striatal activation (F2,210 = 58.8, p < 0.001) during cues to gain or lose $5. We observed a main effect of condition during cue presentation, such that bilateral insula and putamen activation was diminished (p < 0.001) in the scream versus the safe condition. A t-test of condition showed increased activation during threat blocks in the insula and putamen. A time course graph revealed that activation in the insula and putamen responded similarly to incentive but had an overall elevation during the scream condition. These results replicated expected activation in reward and in the setting of uncertain threat. Our results show that uncertain threat increases the magnitude of activation in the dorsal striatum. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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