Imbalance Between Prefronto-Thalamic and Sensorimotor-Thalamic Circuitries Associated with Working Memory Deficit in Schizophrenia.
Background Thalamocortical circuit imbalance characterized by prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity has been consistently documented at rest in schizophrenia (SCZ). However, this thalamocortical imbalance has not been studied during task engagement to date,...
| Published in: | Schizophrenia Bulletin Vol. 48; no. 1; pp. 251 - 262 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Jan2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154897088&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154897088 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: Jan2022 vid: 48 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 154897088 154897088 154897088 10.1093/schbul/sbab086 154897088 ppf: 251 ppct: 11 formats: tig: atl: Imbalance Between Prefronto-Thalamic and Sensorimotor-Thalamic Circuitries Associated with Working Memory Deficit in Schizophrenia. aug: au: Wu, Guowei Palaniyappan, Lena Zhang, Manqi Yang, Jie Xi, Chang Liu, Zhening Xue, Zhimin Ouyang, Xuan Tao, Haojuan Zhang, Jinqiang Luo, Qiang Pu, Weidan affil: Department of Psychiatry, the Second Xiangya Hospital, Central South University , Changsha , China sug: subj: Schizophrenia Memory Disorders Prefrontal Cortex Physiology Thalamus Physiology Large-Scale Brain Networks Functional Connectivity Cognition Disorders Task Performance and Analysis Human Brain Radiography Neural Pathways Correlational Studies Psychomotor Performance Mental Processes Functional Status ab: Background Thalamocortical circuit imbalance characterized by prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity has been consistently documented at rest in schizophrenia (SCZ). However, this thalamocortical imbalance has not been studied during task engagement to date, limiting our understanding of its role in cognitive dysfunction in schizophrenia. Methods Both n-back working memory (WM) task-fMRI and resting-state fMRI data were collected from 172 patients with SCZ and 103 healthy control subjects (HC). A replication sample with 49 SCZ and 48 HC was independently obtained. Sixteen thalamic subdivisions were employed as seeds for the analysis. Results During both task-performance and rest, SCZ showed thalamic hyperconnectivity with sensorimotor cortices, but hypoconnectivity with prefrontal-cerebellar regions relative to controls. Higher sensorimotor-thalamic connectivity and lower prefronto-thalamic connectivity both relate to poorer WM performance (lower task accuracy and longer response time) and difficulties in discriminating target from nontarget (lower d′ score) in n-back task. The prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity were anti-correlated both in SCZ and HCs; this anti-correlation was more pronounced with less cognitive demand (rest>0-back>2-back). These findings replicated well in the second sample. Finally, the hypo- and hyper-connectivity patterns during resting-state positively correlated with the hypo- and hyper-connectivity during 2-back task-state in SCZ respectively. Conclusions The thalamocortical imbalance reflected by prefronto-thalamic hypoconnectivity and sensorimotor-thalamic hyperconnectivity is present both at rest and during task engagement in SCZ and relates to working memory performance. The frontal reduction, sensorimotor enhancement pattern of thalamocortical imbalance is a state-invariant feature of SCZ that affects a core cognitive function. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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