An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful complement to glycated hemoglobin (HbA1c) for the diagnosis and monitoring of diabetes. To date, a single genome-wide association study (GWAS) including 8,951 U.S. White and 2,712 U.S. Black individuals wi...
| Publicado en: | Diabetes Vol. 71; no. 2; pp. 359 - 365 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
American Diabetes Association
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154923845&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154923845 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121797 1G6 jtl: Diabetes issn: 00121797 maglogo: N pubinfo: dt: Feb2022 vid: 71 iid: 2 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 154923845 154923845 NLM34753797 154923845 10.2337/db21-0320 NLM34753797 154923845 ppf: 359 ppct: 6 formats: tig: atl: An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript. aug: au: Riveros-Mckay, Fernando Roberts, David Di Angelantonio, Emanuele Yu, Bing Soranzo, Nicole Danesh, John Selvin, Elizabeth Butterworth, Adam S. Barroso, Inês sug: subj: Calcium Binding Proteins Histocompatibility Antigens Receptors, Cell Surface Carbohydrates Blood Genes Female Diabetes Mellitus, Type 2 Human Sequence Analysis United States Atherosclerosis Blood Adult Prospective Studies Metabolic Networks and Pathways Atherosclerosis Polymorphism, Genetic Genetics Male Diabetes Mellitus, Type 2 Blood Genome Diabetes Mellitus, Type 2 Epidemiology Carbohydrates Atherosclerosis Epidemiology Comparative Studies Multicenter Studies Evaluation Research Validation Studies Funding Source Adult: 19-44 years Female Male ab: Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful complement to glycated hemoglobin (HbA1c) for the diagnosis and monitoring of diabetes. To date, a single genome-wide association study (GWAS) including 8,951 U.S. White and 2,712 U.S. Black individuals without a diabetes diagnosis has been published. Results in Whites and Blacks yielded different association loci, near RCN3 and CNTN5, respectively. In this study, we performed a GWAS on 20,731 European-ancestry blood donors and meta-analyzed our results with previous data from U.S. White participants from the Atherosclerosis Risk in Communities (ARIC) study (Nmeta = 29,685). We identified a novel association near GCK (rs3757840, βmeta = 0.0062; minor allele frequency [MAF] = 0.49; Pmeta = 3.66 × 10-8) and confirmed the association near RCN3 (rs113886122, βmeta = 0.0134; MAF = 0.17; Pmeta = 5.71 × 10-18). Colocalization analysis with whole-blood expression quantitative trait loci data suggested FCGRT as the effector transcript at the RCN3 locus. We further showed that fructosamine has low heritability (h2 = 7.7%), has no significant genetic correlation with HbA1c and other glycemic traits in individuals without a diabetes diagnosis (P > 0.05), but has evidence of shared genetic etiology with some anthropometric traits (Bonferroni-corrected P < 0.0012). Our results broaden knowledge of the genetic architecture of fructosamine and prioritize FCGRT for downstream functional studies at the established RCN3 locus. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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