Mapping the effects of atomoxetine during response inhibition across cortical territories and the locus coeruleus.
Rationale: The effects of atomoxetine (ATO) on response inhibition have been typically examined using the stop signal task (SST) which is however confounded by attentional capture. The right inferior frontal cortex (rIFC) has been implicated in the modulation of ATO on inhibitory control, but a prec...
| Published in: | Psychopharmacology Vol. 239; no. 2; pp. 365 - 377 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Feb2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154981143&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154981143 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2022 vid: 239 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 154981143 153171446 154981143 154981143 10.1007/s00213-021-05998-2 154981143 ppf: 365 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mapping the effects of atomoxetine during response inhibition across cortical territories and the locus coeruleus. aug: au: Ye, Rong Mazibuko, Ndabezinhle Teichert, Jens Regenthal, Ralf Kehagia, Angie A. Mehta, Mitul A. affil: Department of Clinical Neurosciences and Cambridge University Hospital NHS Trust, University of Cambridge, Herchel Smith Building, Robinson Way, CB2 0SZ, Cambridge, UK sug: subj: Atomoxetine Brain Stem Norepinephrine Human Frontal Lobe Descriptive Statistics ab: Rationale: The effects of atomoxetine (ATO) on response inhibition have been typically examined using the stop signal task (SST) which is however confounded by attentional capture. The right inferior frontal cortex (rIFC) has been implicated in the modulation of ATO on inhibitory control, but a precise characterisation of its role is complicated by its functional inhomogeneity. Objectives: The current study aimed to directly investigate the effect of ATO in the SST using the imaging contrast unconfounded by attentional capture, to test the specific drug actions in functionally dissociable rIFC subregions, and to explore the role of locus coeruleus (LC), the main source of cortical noradrenaline, in mediating the drug effects. Methods: This imaging study investigated the effect of ATO (40 mg) in 18 human participants during a modified SST that unconfounds attention from inhibition. Functional definitions for rIFC subdivisions were adopted in the analyses to isolate attention and inhibition during action cancellation. The LC integrity was measured in vivo using a neuromelanin-sensitive sequence. Results: We identified one mechanism of ATO modulation specific to inhibitory control: ATO enhanced activity in pre-supplementary area (pre-SMA) for motor inhibition, and the recruitment of temporoparietal junction (TPJ) and inferior frontal junction (IFJ) for functional integration during response inhibition. Moreover, drug-related behavioural and neural responses correlated with variations in LC integrity. Conclusions: These findings provide a more nuanced and precise understanding of the effects of ATO on specific and domain general aspects of stopping. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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