Sex differences in affective states and association with voluntary ethanol intake in Sprague–Dawley rats.
Alcohol use disorders (AUDs) are a major problem across the USA. While AUD remains a complex human condition, it is difficult to isolate the directionality of anxiety and ethanol (EtOH) drinking from outside influences. The present study sought to investigate the relationship between affective state...
| Publicado en: | Psychopharmacology Vol. 239; no. 2; pp. 589 - 605 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=154981161&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 154981161 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2022 vid: 239 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 154981161 154756023 154981161 154981161 10.1007/s00213-021-06052-x 154981161 ppf: 589 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Sex differences in affective states and association with voluntary ethanol intake in Sprague–Dawley rats. aug: au: Quadir, S. G. Arleth, G. M. Jahad, J. V. Echeveste Sanchez, M. Effinger, D. P. Herman, M. A. affil: Department of Pharmacology, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA sug: subj: Alcohol Drinking Affect Sex Factors Animal Studies Rats Anxiety Depression Pain Threshold ab: Alcohol use disorders (AUDs) are a major problem across the USA. While AUD remains a complex human condition, it is difficult to isolate the directionality of anxiety and ethanol (EtOH) drinking from outside influences. The present study sought to investigate the relationship between affective states and EtOH intake using male and female Sprague–Dawley rats. Using complementary tests of anxiety- and depressive-like behavior, we found sex- and test-specific differences in basal affective behavior such that females displayed enhanced anxiety-like behavior in the splash test and males displayed enhanced anxiety-like behavior in the novelty-suppressed feeding test. Although, there were no sex differences in EtOH intake and no correlation between baseline anxiety-like behavior and subsequent EtOH intake, we did find that depressive-like behavior predicted future EtOH intake in female rats only. In addition, we observed an increase in depressive-like behavior is male rats in both the water and EtOH drinking groups (compared to baseline levels). Furthermore, post-drinking anxiety-like behavior, but not depressive-like behavior predicted subsequent EtOH intake in female rats. Lastly, we found a history of EtOH intake decreased pain thresholds in male and female rats, but increased anxiety-like and depressive-like behavior was associated with decreased thermal sensitivity only in EtOH-drinking males. Together, these experiments provide important information on the complex interaction between negative affect and EtOH intake and how these two contexts reciprocally do, or do not, influence each other in a sex-specific manner. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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