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Evaluation of renal fibrosis in patients with chronic kidney disease by shear wave elastography: a comparative analysis with pathological findings.

Purpose: To explore the elastic values obtained by shear wave elastography (SWE) in assessing renal fibrosis in chronic kidney disease (CKD). Methods: One hundred and twenty-four patients with CKD who underwent renal biopsy were prospectively enrolled between April 2019 and June 2021. SWE was perfor...

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Published in:Abdominal Radiology Vol. 47; no. 2; pp. 738 - 746
Main Authors: Chen, Ziman, Chen, Jiaxin, Chen, Hui, Su, Zhongzhen
Format: diagnostic images research tables/charts Journal Article
Published: Springer Nature Feb2022
Online Access:View this record in EBSCOhost
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      dt: Feb2022
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      pub: Springer Nature
      place: New York, New York
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        154994619
        10.1007/s00261-021-03351-x
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        atl: Evaluation of renal fibrosis in patients with chronic kidney disease by shear wave elastography: a comparative analysis with pathological findings.
      aug:
        au:
          Chen, Ziman
          Chen, Jiaxin
          Chen, Hui
          Su, Zhongzhen
        affil: Department of Ultrasound, Fifth Affiliated Hospital of Sun Yat-Sen University, 519000, Zhuhai, Guangdong, China
      sug:
        subj:
          Kidney Failure, Chronic Ultrasonography
          Shear
          Fibrosis Ultrasonography
          Elasticity Evaluation
          Fibrosis Pathology
          Comparative Studies
          Biopsy
          Prospective Studies
          ROC Curve
          Perfusion
          Descriptive Statistics
          Confidence Intervals
          Odds Ratio
          Human
          Data Analysis Software
          Male
          Female
          Adult
          Middle Age
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Purpose: To explore the elastic values obtained by shear wave elastography (SWE) in assessing renal fibrosis in chronic kidney disease (CKD). Methods: One hundred and twenty-four patients with CKD who underwent renal biopsy were prospectively enrolled between April 2019 and June 2021. SWE was performed to measure the renal cortex stiffness, presented as SWE parameters, including the minimum, mean, and maximum elasticity (namely Emin, Emean, and Emax). Then, the patients with different kidney pathological impairment (mild, moderate, and severe groups) were compared in SWE elasticity and the discriminative capacity was also analyzed. Results: For the pathology impaired grade, SWE parameter was significantly reduced in the moderately and severely impaired group than the mild one. Emax parameter achieved the best discriminative ability toward differentiating moderate–severe impairment from mild one, yielding an area under the curve (AUC) of 0.764 (95%CI: 0.681–0.848). Regarding interstitial fibrosis/tubular atrophy and global glomerular sclerosis, the Emax values were significantly reduced across the group of patients with moderate grade compared to those with mild grade. Patients in severe group were also with reduced elastic value than those in mild one, while the difference was non-significant in interstitial fibrosis/tubular atrophy but a borderline statistical significance was achieved in global glomerular sclerosis. For grade of vessel wall thickening, patients in moderate (33.04 ± 9.86 kPa, P = 0.009) and severe (31.42 ± 9.16 kPa, P < 0.001) group were with significantly lower elastic value compared with those in the mild one (39.58 ± 9.67 kPa). The SWE parameter was linearly reduced as grade of vessel wall thickening elevated (P for trend: < 0.001). Conclusion: SWE derived elastic values reduced as pathology grade of renal fibrosis or grade of vessel wall thickening progresses in patients with CKD, which may be attributed to renal hypo-perfusion rather than tubulo-interstitial fibrosis progression.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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