Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.

Rationale: The alarmins IL-33 and HMGB1 (high mobility group box 1) contribute to type 2 inflammation and asthma pathogenesis. Objectives: To determine whether P2Y13-R (P2Y13 receptor), a purinergic GPCR (G protein-coupled receptor) and risk allele for asthma, regulates the release of IL-33 and HMGB...

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Publicado en:	American Journal of Respiratory & Critical Care Medicine Vol. 205; no. 3; pp. 300 - 340
Autores principales:	Werder, Rhiannon B., Ullah, Md Ashik, Rahman, Muhammed Mahfuzur, Simpson, Jennifer, Lynch, Jason P., Collinson, Natasha, Rittchen, Sonja, Rashid, Ridwan B., Sikder, Md Al Amin, Handoko, Herlina Y., Curren, Bodie F., Sebina, Ismail, Hartel, Gunter, Bissell, Alec, Ngo, Sylvia, Yarlagadda, Tejasri, Hasnain, Sumaira Z., Wenying Lu, Sohal, Sukhwinder S., Martin, Megan
Formato:	research Journal Article
Publicado:	Oxford University Press / USA 2/1/2022
Acceso en línea:	Ver este registro en EBSCOhost