Cystatin C relates to metabolism in healthy, pubertal adolescents.
Introduction: The cystatin C (CysC) serum level is a marker of glomerular filtration rate and depends on age, gender, and pubertal stage. We hypothesize that CysC might overall reflect energy homeostasis and be regulated by components of the endocrine system and metabolites in pubertal adolescents....
| Publicado en: | Pediatric Nephrology Vol. 37; no. 2; pp. 423 - 433 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155078874&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155078874 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Feb2022 vid: 37 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155078874 152074028 155078874 155078874 10.1007/s00467-021-05209-2 155078874 ppf: 423 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cystatin C relates to metabolism in healthy, pubertal adolescents. aug: au: Ziegelasch, Niels Vogel, Mandy Körner, Antje Koch, Eva Jurkutat, Anne Ceglarek, Uta Dittrich, Katalin Kiess, Wieland affil: Hospital for Children and Adolescents, University of Leipzig, Liebigstraße 27b, 04103, Leipzig, Germany sug: subj: Cystatin C Blood Puberty Endocrine System Physiology Hormones Physiology Metabolites Human Female Male Adolescence Blood Specimen Collection Univariate Statistics Multivariate Analysis Data Analysis Software Linear Regression Random Sample Sex Factors Skinfold Thickness Testosterone Blood Follicle-Stimulating Hormone Blood Luteinizing Hormone Blood Thyroid Hormones Blood Parathyroid Hormones Blood Insulin Blood Blood Glucose Proteins Blood gamma-Glutamyltransferase Blood Albumins Blood Urea Blood Alanine Aminotransferase Blood Aspartate Aminotransferase Blood Uric Acid Blood Body Height Age Factors Body Mass Index Glycated Hemoglobin Alkaline Phosphatase Blood Adolescent: 13-18 years Female Male ab: Introduction: The cystatin C (CysC) serum level is a marker of glomerular filtration rate and depends on age, gender, and pubertal stage. We hypothesize that CysC might overall reflect energy homeostasis and be regulated by components of the endocrine system and metabolites in pubertal adolescents. Methods: Serum CysC levels and further possible effector parameters in 5355 fasting, morning venous blood samples from 2035 healthy participants of the LIFE Child cohort study (age 8 to 18 years) were analyzed. Recruitment started in 2011, with probands followed up once a year. Linear univariate and stepwise multivariate regression analyses were performed. Results: Annual growth rate, serum levels of thyroid hormones, parathyroid hormone, insulin-like growth factor 1, hemoglobin A1c (HbA1c), uric acid, and alkaline phosphatase show relevant and significant associations with CysC serum concentrations (p <0.001). Furthermore, male probands' CysC correlated with the body mass index and testosterone among other sexual hormones. Multivariate analyses revealed that uric acid and HbA1c are associated variables of CysC independent from gender (p <0.001). In males, alkaline phosphatase (p <0.001) is additionally significantly associated with CysC. Thyroid hormones show significant correlations only in multivariate analyses in females (p <0.001). Conclusions: The described associations strongly suggest an impact of children's metabolism on CysC serum levels. These alterations need to be considered in kidney diagnostics using CysC in adolescents. Additionally, further studies are needed on CysC in children. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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