Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults.
Purpose: Recent epidemiological evidence has suggested that use of lipid-lowering medications, particularly statins, was associated with reduced cardiovascular disease (CVD) events and persistent physical disability in healthy older adults. However, the comparative efficacy of different statins in t...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 78; no. 3; pp. 467 - 477 |
|---|---|
| Autores principales: | , , , , , , , , , , , , |
| Formato: | algorithm research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155080938&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155080938 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Mar2022 vid: 78 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155080938 153259260 155080938 155080938 10.1007/s00228-021-03239-1 155080938 ppf: 467 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults. aug: au: Zhou, Zhen Curtis, Andrea J. Ernst, Michael E. Ryan, Joanne Zoungas, Sophia Wolfe, Rory McNeil, John J. Murray, Anne M. Reid, Christopher M. Chowdhury, Enayet K. Woods, Robyn L. Tonkin, Andrew M. Nelson, Mark R. affil: Menzies Institute for Medical Research, University of Tasmania, TAS, 17 Liverpool Street, 7000, Hobart, Australia sug: subj: Cardiovascular Diseases Prevention and Control Statins Therapeutic Use Functional Status Human Aged Aged, 80 and Over Post Hoc Analysis Cox Proportional Hazards Model Descriptive Statistics Confidence Intervals Aged: 65+ years Aged, 80 & over ab: Purpose: Recent epidemiological evidence has suggested that use of lipid-lowering medications, particularly statins, was associated with reduced cardiovascular disease (CVD) events and persistent physical disability in healthy older adults. However, the comparative efficacy of different statins in this group remains unclear. This study aimed to compare different forms of statins in their associations with CVD and physical disability in healthy older adults. Methods: This post hoc analysis included data from 5981 participants aged ≥ 70 years (≥ 65 if US minorities; median age:74.0) followed for a median of 4.7 years, who had no prior CVD events or physical disability and reported using a statin at baseline. The incidence of the composite and components of major adverse cardiovascular events and persistent physical disability were compared across different statins according to their type, potency, and lipophilicity using multivariable Cox proportional-hazards models. Results: Atorvastatin was the most used statin type at baseline (37.9%), followed by simvastatin (29.6%), rosuvastatin (25.5%), and other statins (7.0%, predominantly pravastatin). In comparisons of specific statins according to type and lipophilicity (lipophilic vs. hydrophilic statin), observed differences in all outcomes were small and not statistically significant (all p values > 0.05). High-potency statin use (atorvastatin and rosuvastatin) was marginally associated with lower risk of fatal CVD events compared with low-/moderate-potency statin use (hazard ratio: 0.59; 95% confidence interval: 0.35, 1.00). Conclusion: There were minimal differences in CVD outcomes and no significant difference in persistent physical disability between various forms of statins in healthy older adults. Future investigations are needed to confirm our results. pubtype: Academic Journal doctype: algorithm research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|