Trends in the use of oral anticoagulants, antiplatelets and statins in four European countries: a population-based study.
Purpose: To evaluate time trends in the prevalence of antithrombotic and statin use in four European countries. Methods: Using population-based data from the United Kingdom, Denmark, Spain and Italy between 2010 and 2018, we calculated standardized annual prevalence proportions of antithrombotics an...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 78; no. 3; pp. 497 - 505 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155080947&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155080947 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Mar2022 vid: 78 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155080947 153629921 155080947 155080947 10.1007/s00228-021-03250-6 155080947 ppf: 497 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Trends in the use of oral anticoagulants, antiplatelets and statins in four European countries: a population-based study. aug: au: García Rodríguez, Luis A. Cea Soriano, Lucía de Abajo, Francisco J. Valent, Francesca Hallas, Jesper Gil, Miguel Cattaruzzi, Chiara Rodriguez-Martin, Sara Vora, Pareen Soriano-Gabarró, Montse Gaist, David affil: Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain sug: subj: Anticoagulants Therapeutic Use Administration, Oral Platelet Aggregation Inhibitors Therapeutic Use Statins Therapeutic Use Fibrinolytic Agents Therapeutic Use Prescribing Patterns Trends Human Europe Prevalence United Kingdom Denmark Spain Italy Aspirin Administration and Dosage Guideline Adherence ab: Purpose: To evaluate time trends in the prevalence of antithrombotic and statin use in four European countries. Methods: Using population-based data from the United Kingdom, Denmark, Spain and Italy between 2010 and 2018, we calculated standardized annual prevalence proportions of antithrombotics and statin use, and changes in prevalence proportions (2018 vs. 2010). Results: Prevalence proportion of statins increased from 24.8% to 24.6% (UK), 21.0% to 22.3% (Region of Southern Denmark [RSD]), 12.9% to 14.3% (Udine, Italy), and 20.3% to 23.2% (Spain). Prevalence proportions of antithrombotics declined in all four countries: 18.7% to 15.9% (UK; − 2.8% points), 18.9% to 18.1% (RSD; − 0.8% points), 17.7% to 16.6% (Udine; − 1.1% points) and 15.0% to 13.6% (Spain; − 1.4% points). These declines were driven by reductions in low-dose aspirin use: 15.3% to 8.9% (UK; − 6.4% points), 16.3% to 9.5% (RSD; − 6.8% points), 13.5% to 11.6% (Udine; − 1.9% points), and 10.2% to 8.8% (Spain; − 1.4% points). In the UK, low-dose aspirin use declined from 9.1% to 4.3% (− 4.8% points) for primary CVD prevention, and from 49.6% to 36.9% (− 12.7% points) for secondary prevention. Oral anticoagulant use gradually increased but did not fully account for the decrease in low-dose aspirin use. Conclusions: Antithrombotic use in the UK, RSD, Udine and Spain declined between 2010 and 2018, driven by a reduction in use of low-dose aspirin that is not completely explained by a gradual increase in OAC use. Use of statins remained constant in the UK, and increased gradually in the RSD, Udine and Spain. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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