Three‐dimensional right ventriculo‐arterial coupling as an independent determinant of severe heart failure symptoms in patients with dilated cardiomyopathy.
Background: Right ventricular‐pulmonary artery coupling (RVPAC) is a predictor of outcome in pulmonary hypertension. However, the role of this parameter in dilated cardiomyopathy (DCM) remains to be established. The aim of this study was to assess the contribution of RVPAC to the occurrence of sever...
| Publicado en: | Echocardiography Vol. 39; no. 2; pp. 194 - 204 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155106984&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155106984 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Feb2022 vid: 39 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155106984 154527748 155106984 155106984 10.1111/echo.15288 155106984 ppf: 194 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Three‐dimensional right ventriculo‐arterial coupling as an independent determinant of severe heart failure symptoms in patients with dilated cardiomyopathy. aug: au: Vîjîiac, Aura Onciul, Sebastian Deaconu, Silvia Vătășescu, Radu Guzu, Claudia Verinceanu, Violeta Scărlătescu, Alina Zamfir, Diana Petre, Ioana Scafa‐Udriște, Alexandru Dorobanţu, Maria affil: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania sug: subj: Cardiomyopathy, Dilated Echocardiography, Three-Dimensional Heart Ventricle, Right Physiology Arteries Physiology Heart Failure Symptoms Human Prospective Studies Health Screening Descriptive Statistics Confidence Intervals Odds Ratio ab: Background: Right ventricular‐pulmonary artery coupling (RVPAC) is a predictor of outcome in pulmonary hypertension. However, the role of this parameter in dilated cardiomyopathy (DCM) remains to be established. The aim of this study was to assess the contribution of RVPAC to the occurrence of severe heart failure (HF) symptoms in patients with DCM using three‐dimensional (3D) echocardiography. Methods: We prospectively screened 139 outpatients with DCM, 105 of whom were enrolled and underwent 3D echocardiographic assessment. RVPAC was estimated non‐invasively as the 3D right ventricular stroke volume (SV) to end‐systolic volume (ESV) ratio. Severe HF symptoms were defined by New York Heart Association (NYHA) class III or IV. We evaluated differences in RVPAC across NYHA classes and the ability of RVPAC to predict severe symptoms. Results: Mean left ventricular (LV) ejection fraction was 28±7%. Mean RVPAC was 0.77±0.30 and it was significantly more impaired with increasing symptom severity (p = 0.001). RVPAC was the only independent determinant of severe HF symptoms, after adjusting for age, diuretic use, LV systolic function, LV diastolic function, and pulmonary artery systolic pressure (OR 0.035 [95% CI, 0.004–0.312], p = 0.003). By receiver‐operating characteristic analysis, the RVPAC cut‐off value for predicting severely symptomatic status was 0.54 (area under the curve = 0.712, p < 0.001). Conclusion: 3D echocardiographic SV/ESV ratio is an independent correlate of severe HF symptoms in patients with DCM. 3D RVPAC might prove to be a useful risk stratification tool for these patients, should it be further validated in larger studies. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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