Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.
Purpose: Brain involvement in X-linked Charcot-Marie-Tooth disease (CMTX) has been previously reported. We studied the brain structural and functional integrity using a multimodal neuroimaging approach in patients with no current central nervous system (CNS) symptoms, in order to further delineate t...
| Published in: | Neuroradiology Vol. 64; no. 3; pp. 543 - 553 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Mar2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155281105&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155281105 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Mar2022 vid: 64 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155281105 153359961 155281105 155281105 10.1007/s00234-021-02730-x 155281105 ppf: 543 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study. aug: au: Karavasilis, Efstratios Christidi, Foteini Pantou, Eirini Angelopoulou, Georgia Kasselimis, Dimitrios Breza, Marianthi Kontogeorgiou, Zoi Filippiadis, Dimitrios Potagas, Constantin Karadima, Georgia Koutsis, Georgios Velonakis, Georgios affil: 2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece sug: subj: Charcot-Marie-Tooth Disease Brain Anatomy and Histology Genetic Diseases, X-Linked Neuroradiography Phenotype Human Brain Radiography Magnetic Resonance Imaging Gray Matter Analysis Brain Hemispheres Hippocampus Cerebellum ab: Purpose: Brain involvement in X-linked Charcot-Marie-Tooth disease (CMTX) has been previously reported. We studied the brain structural and functional integrity using a multimodal neuroimaging approach in patients with no current central nervous system (CNS) symptoms, in order to further delineate the disease's phenotype. Methods: Seventeen CMTX patients with no current CNS symptoms and 24 matched healthy controls underwent brain magnetic resonance imaging (MRI). Structural integrity was evaluated performing Gray matter analysis with voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI). Functional integrity was evaluated with resting-state functional MRI (rs-fMRI). Results: Decreased gray matter density was detected in CMTX patients compared to healthy controls in bilateral hippocampus, left thalamus, left postcentral gyrus, left superior parietal lobule, left cerebellum crus I and II, and vermis VI. DTI analysis showed increased fractional anisotropy and radial diffusivity in the right anterior insula and increased axial diffusivity in right cerebellum crus I in CMTX patients. rs-fMRI revealed decreased spontaneous neural activity on left precentral gyrus in patients compared to healthy controls. Conclusion: Advanced magnetic resonance (MR) neuroimaging techniques in CMTX patients revealed structural and functional involvement of multiple motor and extra-motor brain areas. MR neuroimaging techniques have the potential to delineate the CNS phenotype of a peripheral neuropathy like CMTX. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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