Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics.
Purpose: We hypothesize that myelin is more susceptible to damage over time than axons. We investigated the association between the estimated duration from the onset of multiple sclerosis (MS) plaques and myelin- and axon-related quantitative synthetic magnetic resonance imaging (SyMRI) and neurite...
| Publicado en: | Neuroradiology Vol. 64; no. 3; pp. 465 - 472 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155281109&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155281109 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Mar2022 vid: 64 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155281109 151871930 155281109 155281109 10.1007/s00234-021-02781-0 155281109 ppf: 465 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics. aug: au: Maekawa, Tomoko Hagiwara, Akifumi Yokoyama, Kazumasa Hori, Masaaki Andica, Christina Fujita, Shohei Kamagata, Koji Wada, Akihiko Abe, Osamu Tomizawa, Yuji Hattori, Nobutaka Aoki, Shigeki affil: Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan sug: subj: Multiple Sclerosis Pathology Nerve Tissue Pathology Nerve Fibers Magnetic Resonance Imaging Methods Human Cross Sectional Studies Quantitative Studies Linear Regression White Matter Descriptive Statistics ab: Purpose: We hypothesize that myelin is more susceptible to damage over time than axons. We investigated the association between the estimated duration from the onset of multiple sclerosis (MS) plaques and myelin- and axon-related quantitative synthetic magnetic resonance imaging (SyMRI) and neurite orientation dispersion and density imaging (NODDI) metrics. Methods: We analyzed 31 patients with MS with 73 newly appeared plaques. Simple linear regression analysis was performed to assess the association between the estimated duration from the onset of plaques and quantitative MRI metrics. These metrics included the myelin volume fraction (MVF), axon volume fraction, and g-ratio in plaque and normal-appearing white matter. Results: MS plaques with a longer estimated duration from onset were significantly correlated with a lower MVF (slope = − 0.0070, R2 = 0.0970), higher g-ratio (slope = 0.0078, R2 = 0.0842) (all P values < 0.05). Conclusion: These results suggested that myelin in plaques undergoes continuous damage, more so than axons. Myelin imaging with SyMRI and NODDI may be useful for the quantitative assessment of temporal changes in MS plaques. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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