Positive Anti-HIV ELISA Results in Pregnancy: Is It Reliable?
Background: Human immunodeficiency virus (HIV) can be transmitted from mothers to their babies during pregnancy, delivery through vaginal fluids or breastfeeding. As false positivity anti-HIV results due to pregnancy could be detected and no relevant study have been reported in Northern Cyprus so fa...
| Publicado en: | Infectious Diseases in Obstetrics & Gynecology pp. 1 - 7 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2/16/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155288516&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155288516 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10647449 O5Q jtl: Infectious Diseases in Obstetrics & Gynecology issn: 10647449 maglogo: N pubinfo: dt: 2/16/2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 155288516 155288516 NLM35221647 10.1155/2022/1157793 NLM35221647 155288516 ppf: 1 ppct: 6 formats: tig: atl: Positive Anti-HIV ELISA Results in Pregnancy: Is It Reliable? aug: au: Güler, Emrah Arıkan, Ayşe Abobakr, Mariam Sayan, Murat Süer, Kaya Şanlıdağ, Tamer affil: Department of Nutrition and Dietetics, Faculty of Health Sciences, Near East University, Nicosia, Cyprus sug: subj: HIV-1 Pregnancy Complications, Infectious Drug Therapy Pregnancy Complications, Infectious Diagnosis HIV Infections Diagnosis HIV Infections Drug Therapy Female Anti-Retroviral Agents Therapeutic Use Pregnancy Disease Transmission, Vertical Enzyme-Linked Immunosorbent Assay Social Readjustment Rating Scale Female ab: Background: Human immunodeficiency virus (HIV) can be transmitted from mothers to their babies during pregnancy, delivery through vaginal fluids or breastfeeding. As false positivity anti-HIV results due to pregnancy could be detected and no relevant study have been reported in Northern Cyprus so far, we aimed to estimate the false anti-HIV positivity rate in pregnant women.Methods: A total of 11.977 women admitted to Near East University Hospital between 2015 and 2018 were involved. The fourth generation anti-HIV-1/2 ELISA test was carried out by chemiluminescence enzyme immunoassay. Positive results were confirmed by real-time polymerase chain reaction (rt-PCR). SPSS (Statistical Package for the Social Sciences) Demo Ver 22 program was used for statistical analysis and significance (p<0.05) was measured by Person Chi-Square and Fisher's Exact tests.Results: Anti-HIV-1/2 ELISA test was positive in 7 (0.3%) of pregnant and 11 (0.1%) of non-pregnant women. HIV RNA was not detected in any pregnant however, was detected in 2 (0.02%) of non pregnant. S/Co titer of pregnant and non pregnant who have positive anti-HIV-test without viral load was x̄=2.68±1.64 (1.34-5.20) and x̄=8.63±7.68 (1.56-20.98) respectively. False positivity was significantly higher in pregnants compared to non-pregnants (p=0.033).Conclusion: False positivity can be encountered during pregnancy therefore, positive anti-HIV-1/2 ELISA results should be confirmed with molecular techniques before initiating antiretroviral treatment. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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