A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study.
Purpose: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We aimed to identify a plasma fatty acid (FA) profile associated with T2DM developme...
| Published in: | European Journal of Nutrition Vol. 61; no. 2; pp. 843 - 858 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Mar2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155312850&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155312850 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2022 vid: 61 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 155312850 152812800 155312850 155312850 10.1007/s00394-021-02676-z 155312850 ppf: 843 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study. aug: au: Villasanta-Gonzalez, Alejandro Alcala-Diaz, Juan Francisco Vals-Delgado, Cristina Arenas, Antonio Pablo Cardelo, Magdalena P. Romero-Cabrera, Juan Luis Rodriguez-Cantalejo, Fernando Delgado-Lista, Javier Malagon, Maria M. Perez-Martinez, Pablo Schulze, Matthias B. Camargo, Antonio Lopez-Miranda, Jose affil: Lipids and Atherosclerosis Unit, Internal Medicine Unit, Reina Sofia University Hospital, Av. Menendez Pidal, s/n., 14004, Córdoba, Spain sug: subj: Fatty Acids Blood Biological Markers Blood Early Diagnosis Diabetes Mellitus, Type 2 Risk Factors Risk Assessment Diabetes Mellitus, Type 2 Prognosis Human Prevalence Cardiac Patients American Diabetes Association Descriptive Statistics Survival Analysis Confidence Intervals Prediction Models ab: Purpose: The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We aimed to identify a plasma fatty acid (FA) profile associated with T2DM development. Methods: We included 462 coronary heart disease patients from the CORDIOPREV study without T2DM at baseline. Of these, 107 patients developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow-up of 60 months. We performed a random classification of patients in a training set, used to build a FA Score, and a Validation set, in which we tested the FA Score. Results: FA selection with the highest prediction power was performed by random survival forest in the Training set, which yielded 4 out of the 24 FA: myristic, petroselinic, α-linolenic and arachidonic acids. We built a FA Score with the selected FA and observed that patients with a higher score presented a greater risk of T2DM development, with an HR of 3.15 (95% CI 2.04–3.37) in the Training set, and an HR of 2.14 (95% CI 1.50–2.84) in the Validation set, per standard deviation (SD) increase. Moreover, patients with a higher FA Score presented lower insulin sensitivity and higher hepatic insulin resistance (p < 0.05). Conclusion: Our results suggest that a detrimental FA plasma profile precedes the development of T2DM in patients with coronary heart disease, and that this FA profile can, therefore, be used as a predictive biomarker. Clinical Trials.gov.Identifier: NCT00924937. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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