Functional Neural Correlates of Semantic Fluency Task Performance in Mild Cognitive Impairment and Alzheimer's Disease: An FDG-PET Study.
Background: Total score (TS) of semantic verbal fluency test (SVFT) is generally used to interpret results, but it is ambiguous as to specific neural functions it reflects. Different SVFT strategy scores reflecting qualitative aspects are proposed to identify specific cognitive functions to overcome...
| Publicado en: | Journal of Alzheimer's Disease Vol. 85; no. 4; pp. 1689 - 1701 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155334009&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155334009 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2022 vid: 85 iid: 4 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 155334009 155334009 NLM34958036 155334009 10.3233/JAD-215292 NLM34958036 155334009 ppf: 1689 ppct: 12 formats: tig: atl: Functional Neural Correlates of Semantic Fluency Task Performance in Mild Cognitive Impairment and Alzheimer's Disease: An FDG-PET Study. aug: au: Ahn, Hyejin Yi, Dahyun Chu, Kyungjin Joung, Haejung Lee, Younghwa Jung, Gijung Sung, Kiyoung Han, Dongkyun Lee, Jun Ho Byun, Min Soo Lee, Dong Young affil: Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea sug: subj: Alzheimer's Disease Metabolism Semantics Neuropsychological Tests Statistics and Numerical Data Task Performance and Analysis Human Male Brain Metabolism Tomography, Emission-Computed Fludeoxyglucose F 18 Metabolism Aged Female Comparative Studies Multicenter Studies Evaluation Research Validation Studies Clinical Assessment Tools Funding Source Aged: 65+ years Male Female ab: Background: Total score (TS) of semantic verbal fluency test (SVFT) is generally used to interpret results, but it is ambiguous as to specific neural functions it reflects. Different SVFT strategy scores reflecting qualitative aspects are proposed to identify specific cognitive functions to overcome limitations of using the TS.Objective: Functional neural correlates of the TS as well as the other strategy scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using Fluorine-18-Fluorodeoxyglucose positron emission tomography (FDG-PET).Methods: Correlations between various SVFT scores (i.e., TS, mean cluster size, switching (SW), hard switching, cluster switching (CSW)) and cerebral glucose metabolism were explored using voxelwise whole-brain approach. Subgroup analyses were also performed based on the diagnosis and investigated the effects of disease severity on the associations.Results: Significant positive correlation between TS and cerebral glucose metabolism was found in prefrontal, parietal, cingulate, temporal cortex, and subcortical regions. Significantly increased glucose metabolism associated with the SW were found in similar but smaller regions, mainly in the fronto-parieto-temporal regions. CSW was only correlated with the caudate. In the subgroup analysis conducted to assess different contribution of clinical severity, differential associations between the strategy scores and regional glucose metabolism were found.Conclusion: SW and CSW may reflect specific language and executive functions better than the TS. The SVFT is influenced by brain dysfunction due to the progression of AD, as demonstrated by the SW with larger involvement of temporal lobe for the AD, and CSW with significant association only for the MCI. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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