IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET).

Background: Few new drugs have been developed for chronic pain. Drug development is challenged by uncertainty about whether the drug engages the human target sufficiently to have a meaningful pharmacodynamic effect. IMI2-PainCare-BioPain-RCT1 is one of four similarly designed studies that aim to lin...

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Publicado en:	Trials Vol. 23; no. 1; pp. 1 - 21
Autores principales:	Nochi, Zahra, Pia, Hossein, Bloms-Funke, Petra, Boesl, Irmgard, Caspani, Ombretta, Chapman, Sonya C., Fardo, Francesca, Genser, Bernd, Goetz, Marcus, Kostenko, Anna V., Leone, Caterina, Li, Thomas, Mouraux, André, Pelz, Bernhard, Pogatzki-Zahn, Esther, Schilder, Andreas, Schnetter, Erik, Schubart, Karin, Stouffs, Alexandre, Tracey, Irene
Formato:	Journal Article
Publicado:	BioMed Central 2/19/2022
Acceso en línea:	Ver este registro en EBSCOhost