Impact of 18-Month Soy Protein Supplementation on Steroid Hormones and Serum Biomarkers of Angiogenesis, Apoptosis, and the Growth Hormone/IGF-1 Axis: Results of a Randomized, Placebo-Controlled Trial in Males Following Prostatectomy.
Many studies have addressed the effects of dietary supplementation with soy protein on cancer risk and mortality, but there are only few randomized studies with soy in males. We used serum samples from a two-year trial of soy protein isolate supplementation in middle-aged to older males at risk of r...
| Published in: | Nutrition & Cancer Vol. 74; no. 1; pp. 110 - 122 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Taylor & Francis Ltd
2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=155345604&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 155345604 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2022 vid: 74 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 155345604 148032857 155345604 155345604 10.1080/01635581.2020.1870706 155345604 ppf: 110 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Impact of 18-Month Soy Protein Supplementation on Steroid Hormones and Serum Biomarkers of Angiogenesis, Apoptosis, and the Growth Hormone/IGF-1 Axis: Results of a Randomized, Placebo-Controlled Trial in Males Following Prostatectomy. aug: au: Bosland, Maarten C. Huang, Jonathan Schlicht, Michael J. Enk, Erika Xie, Hui Kato, Ikuko affil: Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA sug: subj: Dietary Supplementation Soy Proteins Biological Markers Blood Apoptosis Human Growth Hormone Neovascularization, Physiologic Prostatectomy Postoperative Period Human Randomized Controlled Trials Random Assignment Serum Male Middle Age Aged Genistein Testosterone Estradiol Vascular Endothelial Growth Factors Fibroblast Growth Factors Middle Aged: 45-64 years Aged: 65+ years Male ab: Many studies have addressed the effects of dietary supplementation with soy protein on cancer risk and mortality, but there are only few randomized studies with soy in males. We used serum samples from a two-year trial of soy protein isolate supplementation in middle-aged to older males at risk of recurrence of prostate cancer after radical prostatectomy to determine soy effects on steroid hormones involved in prostate cancer (testosterone, SHBG, and estradiol) and explore the effects on biomarkers of the growth hormone/IGF-1 axis, apoptosis, and angiogenesis. Compared with a casein-based placebo, 18 mo, of consumption of 19.2 g/day of whole soy protein isolate containing 24 mg genistein-reduced circulating testosterone and SHBG, but not free testosterone, and did not affect serum concentrations of estradiol, VEGF, IGF-1, IGFBP-3, IGF-1/IGFBP-3 ratio, soluble Fas, Fas-ligand, and sFas/Fas-ligand ratio. Thus, soy protein supplementation for 18 mo, affected the androgen axis, but the effects on other cancer biomarkers remain to be more definitively determined. The study was registered at clinicaltrials.gov (NCT00765479). pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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